Belend Ismail, Puria Nabilou, Lise Lotte Gluud, Søren Møller
{"title":"MASLD对心血管的影响：证据综述。","authors":"Belend Ismail, Puria Nabilou, Lise Lotte Gluud, Søren Møller","doi":"10.1080/00365521.2025.2536585","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and encompasses a spectrum from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), with potential progression to advanced fibrosis and cirrhosis.</p><p><strong>Objective: </strong>This review provides an overview of the link between MASLD and cardiovascular disease.</p><p><strong>Results: </strong>MASLD is closely linked to metabolic syndrome (MS) and cardiovascular disease, evidenced by increased coronary artery calcification, carotid intima-media thickness, epicardial adipose tissue, and pulse wave velocity, along with decreased flow-mediated dilation. These cardiovascular complications significantly heighten the risk of cardiovascular events and overall mortality.</p><p><strong>Conclusion: </strong>MASLD seems to be an independent cardiovascular risk factor, but further studies are warranted to clarify the distinct impacts of MASLD stages and their interplay with MS on cardiovascular outcomes.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"910-918"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardiovascular implications of MASLD: overview of the evidence.\",\"authors\":\"Belend Ismail, Puria Nabilou, Lise Lotte Gluud, Søren Møller\",\"doi\":\"10.1080/00365521.2025.2536585\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and encompasses a spectrum from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), with potential progression to advanced fibrosis and cirrhosis.</p><p><strong>Objective: </strong>This review provides an overview of the link between MASLD and cardiovascular disease.</p><p><strong>Results: </strong>MASLD is closely linked to metabolic syndrome (MS) and cardiovascular disease, evidenced by increased coronary artery calcification, carotid intima-media thickness, epicardial adipose tissue, and pulse wave velocity, along with decreased flow-mediated dilation. These cardiovascular complications significantly heighten the risk of cardiovascular events and overall mortality.</p><p><strong>Conclusion: </strong>MASLD seems to be an independent cardiovascular risk factor, but further studies are warranted to clarify the distinct impacts of MASLD stages and their interplay with MS on cardiovascular outcomes.</p>\",\"PeriodicalId\":21461,\"journal\":{\"name\":\"Scandinavian Journal of Gastroenterology\",\"volume\":\" \",\"pages\":\"910-918\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian Journal of Gastroenterology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00365521.2025.2536585\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian Journal of Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00365521.2025.2536585","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/28 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Cardiovascular implications of MASLD: overview of the evidence.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and encompasses a spectrum from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), with potential progression to advanced fibrosis and cirrhosis.
Objective: This review provides an overview of the link between MASLD and cardiovascular disease.
Results: MASLD is closely linked to metabolic syndrome (MS) and cardiovascular disease, evidenced by increased coronary artery calcification, carotid intima-media thickness, epicardial adipose tissue, and pulse wave velocity, along with decreased flow-mediated dilation. These cardiovascular complications significantly heighten the risk of cardiovascular events and overall mortality.
Conclusion: MASLD seems to be an independent cardiovascular risk factor, but further studies are warranted to clarify the distinct impacts of MASLD stages and their interplay with MS on cardiovascular outcomes.
期刊介绍：
The Scandinavian Journal of Gastroenterology is one of the most important journals for international medical research in gastroenterology and hepatology with international contributors, Editorial Board, and distribution
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