{"title":"选定生物碱对出生后神经发生的影响-体内和体外研究-文献综述。","authors":"Bartłomiej Kwiatkowski, Natalia Biedroń, Urszula Gawryś, Wiktoria Tochman, Alicja Szklarska, Dorota Luchowska-Kocot","doi":"10.1007/s00213-025-06856-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Rationale: </strong>Postnatal neurogenesis is the process of new nerve cell formation that occurs after birth. The disruption of the neurogenesis process is a significant hypothesis in the development of mental disorders and diseases such as depression, anxiety disorders or schizophrenia, as well as neurodegenerative diseases such as Alzheimer's disease.</p><p><strong>Objective: </strong>The objective of this study was to investigate, based on the existing literature, whether naturally occurring alkaloids have an impact on postnatal neurogenesis and, if so, whether this effect is beneficial or detrimental.</p><p><strong>Methods: </strong>An advanced search was conducted using the databases PubMed and Google Scholar, employing the terms \"alkaloid\" AND \"neurogenesis.\" The research focused on in vitro studies using cell lines, including C17.2, HT-22, BV-2, and SH-SY5Y, in addition to in vivo studies involving zebrafish (Danio rerio), Wistar rats and mice.</p><p><strong>Results: </strong>The research indicated that some of the alkaloids have a beneficial impact on postnatal neurogenesis through their pleiotropic mechanisms of action. This is evidenced by their anti-inflammatory and anti-oxidant effects, ability to increase brain-derived neurotrophic factor (BDNF) levels, promotion of synapse formation, and direct effect on neural progenitor cells proliferation. However, some alkaloids have been shown to have a negative effect on postnatal neurogenesis through mechanisms that are the opposite of those mentioned above.</p><p><strong>Conclusion: </strong>There is currently a lack of consensus on whether neurogenesis occurs in Homo sapiens. However, it is known that alkaloids affect the model organisms in different ways, which suggests a potential for these substances to be used therapeutically. Further research is therefore required to investigate this possibility.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review.\",\"authors\":\"Bartłomiej Kwiatkowski, Natalia Biedroń, Urszula Gawryś, Wiktoria Tochman, Alicja Szklarska, Dorota Luchowska-Kocot\",\"doi\":\"10.1007/s00213-025-06856-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale: </strong>Postnatal neurogenesis is the process of new nerve cell formation that occurs after birth. The disruption of the neurogenesis process is a significant hypothesis in the development of mental disorders and diseases such as depression, anxiety disorders or schizophrenia, as well as neurodegenerative diseases such as Alzheimer's disease.</p><p><strong>Objective: </strong>The objective of this study was to investigate, based on the existing literature, whether naturally occurring alkaloids have an impact on postnatal neurogenesis and, if so, whether this effect is beneficial or detrimental.</p><p><strong>Methods: </strong>An advanced search was conducted using the databases PubMed and Google Scholar, employing the terms \\\"alkaloid\\\" AND \\\"neurogenesis.\\\" The research focused on in vitro studies using cell lines, including C17.2, HT-22, BV-2, and SH-SY5Y, in addition to in vivo studies involving zebrafish (Danio rerio), Wistar rats and mice.</p><p><strong>Results: </strong>The research indicated that some of the alkaloids have a beneficial impact on postnatal neurogenesis through their pleiotropic mechanisms of action. This is evidenced by their anti-inflammatory and anti-oxidant effects, ability to increase brain-derived neurotrophic factor (BDNF) levels, promotion of synapse formation, and direct effect on neural progenitor cells proliferation. However, some alkaloids have been shown to have a negative effect on postnatal neurogenesis through mechanisms that are the opposite of those mentioned above.</p><p><strong>Conclusion: </strong>There is currently a lack of consensus on whether neurogenesis occurs in Homo sapiens. However, it is known that alkaloids affect the model organisms in different ways, which suggests a potential for these substances to be used therapeutically. Further research is therefore required to investigate this possibility.</p>\",\"PeriodicalId\":20783,\"journal\":{\"name\":\"Psychopharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00213-025-06856-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00213-025-06856-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review.
Rationale: Postnatal neurogenesis is the process of new nerve cell formation that occurs after birth. The disruption of the neurogenesis process is a significant hypothesis in the development of mental disorders and diseases such as depression, anxiety disorders or schizophrenia, as well as neurodegenerative diseases such as Alzheimer's disease.
Objective: The objective of this study was to investigate, based on the existing literature, whether naturally occurring alkaloids have an impact on postnatal neurogenesis and, if so, whether this effect is beneficial or detrimental.
Methods: An advanced search was conducted using the databases PubMed and Google Scholar, employing the terms "alkaloid" AND "neurogenesis." The research focused on in vitro studies using cell lines, including C17.2, HT-22, BV-2, and SH-SY5Y, in addition to in vivo studies involving zebrafish (Danio rerio), Wistar rats and mice.
Results: The research indicated that some of the alkaloids have a beneficial impact on postnatal neurogenesis through their pleiotropic mechanisms of action. This is evidenced by their anti-inflammatory and anti-oxidant effects, ability to increase brain-derived neurotrophic factor (BDNF) levels, promotion of synapse formation, and direct effect on neural progenitor cells proliferation. However, some alkaloids have been shown to have a negative effect on postnatal neurogenesis through mechanisms that are the opposite of those mentioned above.
Conclusion: There is currently a lack of consensus on whether neurogenesis occurs in Homo sapiens. However, it is known that alkaloids affect the model organisms in different ways, which suggests a potential for these substances to be used therapeutically. Further research is therefore required to investigate this possibility.
期刊介绍：
Official Journal of the European Behavioural Pharmacology Society (EBPS)
Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields:
Human Psychopharmacology: Experimental
This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered.
Human Psychopharmacology: Clinical and Translational
This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects.
Preclinical psychopharmacology: Behavioral and Neural
This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels.
Preclinical Psychopharmacology: Translational
This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways.
Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic
This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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