再论次水杨酸铋预防旅行者腹泻的疗效。

IF 6.4 2区医学 Q1 INFECTIOUS DISEASES

Journal of travel medicine Pub Date : 2025-10-01 DOI:10.1093/jtm/taaf076

Roger D Gibb, Jose M Brum, Kyle J Sloan, Adam M Pitz, Benjamin T Circello, Rowan A Grayling

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引用次数: 0

摘要

从一项跨越5年但未能实现目标入组、产生与现有知识体系相矛盾的平淡结果、主要疗效终点与covid治疗相互作用相混淆的临床试验中可以得出什么结论？会不会是假阴性呢？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Revisiting the efficacy of bismuth subsalicylate for the prevention of traveller's diarrhoea.

查看原文本刊更多论文

Revisiting the efficacy of bismuth subsalicylate for the prevention of traveller's diarrhoea.

What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a treatment-by-COVID interaction? Could it be a false negative finding?

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来源期刊

Journal of travel medicine 医学-医学：内科

CiteScore

20.90

自引率

5.10%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The Journal of Travel Medicine is a publication that focuses on travel medicine and its intersection with other disciplines. It publishes cutting-edge research, consensus papers, policy papers, and expert reviews. The journal is affiliated with the Asia Pacific Travel Health Society. The journal's main areas of interest include the prevention and management of travel-associated infections, non-communicable diseases, vaccines, malaria prevention and treatment, multi-drug resistant pathogens, and surveillance on all individuals crossing international borders. The Journal of Travel Medicine is indexed in multiple major indexing services, including Adis International Ltd., CABI, EBSCOhost, Elsevier BV, Gale, Journal Watch Infectious Diseases (Online), MetaPress, National Library of Medicine, OCLC, Ovid, ProQuest, Thomson Reuters, and the U.S. National Library of Medicine.