U-BET(用于极低胎龄输血的脐带血)临床试验的设计需要三项研究。

IF 2.4 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Timothy M Bahr, Robin K Ohls, Thomas R Christensen, Martha C Monson, Jessica M Page, Heather A Dabling, James Cole Elliott, Sarah J Ilstrup, Robert D Christensen
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引用次数: 0

摘要

目的:开展“U-BET”试验(超低胎龄输血脐带血)所需的三项研究。研究设计:(1)基于问卷调查的Intermountain Health产科医生抽取脐带血的自我评估。(2)确定有可能献血的O型血新生儿的百分比(用于U-BET)。(3)使用美国红十字会采集试剂盒定量采集脐带血。结果:(1)72%的受访者表示有抽取脐带血的经历;62%胎盘在子宫内。(2)在过去10万名分娩妇女中,48%为O型血,她们所生的新生儿66%为O型血。(3)10例分娩中,胎盘娩出后获得的脐带血容量在20 ~ 86 mL之间,而子宫内获得的脐带血容量在14 ~ 157 mL之间。结论:U-BET试验将同意O型妇女,并使用红十字会试剂盒在胎盘仍在子宫内时抽取足月脐带血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Three studies needed to inform the design of the U-BET (umbilical cord blood for extremely low-gestational-age transfusions) clinical trial.

Objective: To perform three studies needed to design the "U-BET" trial (Umbilical cord Blood for Extremely-low-gestational-age Transfusions).

Study design: (1) Survey-based self-assessment of Intermountain Health obstetricians regarding drawing umbilical cord blood. (2) Determine the percentage of the potentially donating neonates who have type O blood (to be utilized in U-BET). (3) Quantify cord blood drawn using American Red Cross collection kits.

Results: (1) 72% of respondents declared experience drawing cord blood; 62% with the placenta in utero. (2) Of the past 100,000 women delivering, 48% were type O, and 66% of neonates born to them were type O. (3) The volume of cord blood obtained at 10 births ranged from 20 to 86 mL after the placenta was delivered vs. 14 to157 mL when in utero.

Conclusion: The U-BET trial will consent type O women and use Red Cross kits to draw term umbilical cord blood while the placenta is still in utero.

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来源期刊
Journal of Perinatology
Journal of Perinatology 医学-妇产科学
CiteScore
5.40
自引率
6.90%
发文量
284
审稿时长
3-8 weeks
期刊介绍: The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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