Sarah Emily Melo da Silva, Romana Rênery Fernandes, Maria Eduarda Marques da Silva, Héverton Oliveira Duarte, Rosângela Oliveira da Câmara, Maria Luiza Diniz de Sousa Lopes, Ana Rafaela Luz de Aquino Martins, Éricka Janine Dantas Da Silveira
{"title":"重症监护病房患者口腔念珠菌病和唾液分泌不足的相关因素：一项前瞻性队列研究。","authors":"Sarah Emily Melo da Silva, Romana Rênery Fernandes, Maria Eduarda Marques da Silva, Héverton Oliveira Duarte, Rosângela Oliveira da Câmara, Maria Luiza Diniz de Sousa Lopes, Ana Rafaela Luz de Aquino Martins, Éricka Janine Dantas Da Silveira","doi":"10.1007/s00784-025-06465-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To separately investigate the occurrence of oral candidosis and hyposalivation in Intensive Care Unit (ICU) patients and identify contributing factors.</p><p><strong>Methods: </strong>A prospective cohort study was conducted with 100 ICU patients in a hospital in northeastern Brazil. Detailed intraoral examinations were performed daily by calibrated dentists, and sociodemographic and general health-related data were extracted from medical records. Pearson's Chi-square or Fisher's exact test assessed variable associations. Survival analysis estimated the onset time of oral candidosis and hyposalivation and their associations with risk factors.</p><p><strong>Results: </strong>Among the 100 patients, 65% developed hyposalivation, and 11% presented oral candidiasis. The median age was 64 years, with a predominance of males. No significant associations were found between oral candidiasis and demographic or clinical variables. Hyposalivation was significantly linked to underlying renal disease, anemia, and the use of medications such as antibiotics, corticosteroids, anticholinergics, and bronchodilators. Co-occurrence of candidosis and hyposalivation were observed in 7 patients. There was no statistically significant association of the development of oral candidosis or hyposalivation with other oral changes. Anticoagulant use was significantly associated with a higher oral candidiasis-free survival rate. Underlying renal disease, antibiotic treatment, and orotracheal intubation were significantly associated with a reduced survival rate free from hyposalivation.</p><p><strong>Conclusions: </strong>Hyposalivation was highly prevalent and may be linked to the development of other oral conditions, such as oral candidosis. Understanding factors that contribute to hyposalivation and oral candidosis is essential for improving ICU healthcare and enhancing patient recovery.</p><p><strong>Clinical relevance: </strong>Early identification and management of hyposalivation should be prioritized in ICU protocols to enhance patient recovery and oral health care.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"392"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Factors associated with oral candidosis and hyposalivation in intensive care unit patients: a prospective cohort study.\",\"authors\":\"Sarah Emily Melo da Silva, Romana Rênery Fernandes, Maria Eduarda Marques da Silva, Héverton Oliveira Duarte, Rosângela Oliveira da Câmara, Maria Luiza Diniz de Sousa Lopes, Ana Rafaela Luz de Aquino Martins, Éricka Janine Dantas Da Silveira\",\"doi\":\"10.1007/s00784-025-06465-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To separately investigate the occurrence of oral candidosis and hyposalivation in Intensive Care Unit (ICU) patients and identify contributing factors.</p><p><strong>Methods: </strong>A prospective cohort study was conducted with 100 ICU patients in a hospital in northeastern Brazil. Detailed intraoral examinations were performed daily by calibrated dentists, and sociodemographic and general health-related data were extracted from medical records. Pearson's Chi-square or Fisher's exact test assessed variable associations. Survival analysis estimated the onset time of oral candidosis and hyposalivation and their associations with risk factors.</p><p><strong>Results: </strong>Among the 100 patients, 65% developed hyposalivation, and 11% presented oral candidiasis. The median age was 64 years, with a predominance of males. No significant associations were found between oral candidiasis and demographic or clinical variables. Hyposalivation was significantly linked to underlying renal disease, anemia, and the use of medications such as antibiotics, corticosteroids, anticholinergics, and bronchodilators. Co-occurrence of candidosis and hyposalivation were observed in 7 patients. There was no statistically significant association of the development of oral candidosis or hyposalivation with other oral changes. Anticoagulant use was significantly associated with a higher oral candidiasis-free survival rate. Underlying renal disease, antibiotic treatment, and orotracheal intubation were significantly associated with a reduced survival rate free from hyposalivation.</p><p><strong>Conclusions: </strong>Hyposalivation was highly prevalent and may be linked to the development of other oral conditions, such as oral candidosis. Understanding factors that contribute to hyposalivation and oral candidosis is essential for improving ICU healthcare and enhancing patient recovery.</p><p><strong>Clinical relevance: </strong>Early identification and management of hyposalivation should be prioritized in ICU protocols to enhance patient recovery and oral health care.</p>\",\"PeriodicalId\":10461,\"journal\":{\"name\":\"Clinical Oral Investigations\",\"volume\":\"29 8\",\"pages\":\"392\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oral Investigations\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00784-025-06465-4\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00784-025-06465-4","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Factors associated with oral candidosis and hyposalivation in intensive care unit patients: a prospective cohort study.
Objective: To separately investigate the occurrence of oral candidosis and hyposalivation in Intensive Care Unit (ICU) patients and identify contributing factors.
Methods: A prospective cohort study was conducted with 100 ICU patients in a hospital in northeastern Brazil. Detailed intraoral examinations were performed daily by calibrated dentists, and sociodemographic and general health-related data were extracted from medical records. Pearson's Chi-square or Fisher's exact test assessed variable associations. Survival analysis estimated the onset time of oral candidosis and hyposalivation and their associations with risk factors.
Results: Among the 100 patients, 65% developed hyposalivation, and 11% presented oral candidiasis. The median age was 64 years, with a predominance of males. No significant associations were found between oral candidiasis and demographic or clinical variables. Hyposalivation was significantly linked to underlying renal disease, anemia, and the use of medications such as antibiotics, corticosteroids, anticholinergics, and bronchodilators. Co-occurrence of candidosis and hyposalivation were observed in 7 patients. There was no statistically significant association of the development of oral candidosis or hyposalivation with other oral changes. Anticoagulant use was significantly associated with a higher oral candidiasis-free survival rate. Underlying renal disease, antibiotic treatment, and orotracheal intubation were significantly associated with a reduced survival rate free from hyposalivation.
Conclusions: Hyposalivation was highly prevalent and may be linked to the development of other oral conditions, such as oral candidosis. Understanding factors that contribute to hyposalivation and oral candidosis is essential for improving ICU healthcare and enhancing patient recovery.
Clinical relevance: Early identification and management of hyposalivation should be prioritized in ICU protocols to enhance patient recovery and oral health care.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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