{"title":"乳糜泻和皮肤病：一项双向孟德尔随机研究。","authors":"Chenyang Ge, Yizheng Wang, Xuegang Zhao, Jiawen Hao, Jing Zhang, Mengyuan Lu, Congying Li, Jianke Feng, Qingfu Zhang","doi":"10.2147/CCID.S533378","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Research as shown that celiac disease (CD) is associated with skin diseases, but their causality remains unclear. Therefore, this Mendelian randomization (MR) study evaluated the causality between CD and skin diseases.</p><p><strong>Methods: </strong>Bidirectional MR analysis was performed on single nucleotide polymorphism (SNP) candidates identified from genome-wide association study (GWAS) datasets using inverse variance weighted (IVW), weighted median, MR-egger, weighted mode and simple mode. Multivariate MR (MVMR) analysis was subsequently conducted by adjusting for BMI, smoking, and alcohol use. Result reliability was assessed by horizontal pleiotropy and heterogeneity testing.</p><p><strong>Results: </strong>IVW analysis revealed that CD increased the risk of atopic dermatitis (OR = 1.042, 95% CI: 1.018-1.067, <i>P</i> = 5.75 × 10<sup>-4</sup>) and cellulitis (OR = 1.026, 95% CI: 1.006-1.046, <i>P</i> = 9.18×10<sup>-3</sup>). Additionally, psoriasis had a suggestive association with CD (OR=0.836, 95% CI: 0.710-0.983, <i>P</i> = 0.031). MVMR analysis demonstrated that CD had a direct effect on atopic dermatitis and cellulitis.</p><p><strong>Conclusion: </strong>CD contributes to higher risks of atopic dermatitis and cellulitis. Additionally, psoriasis is suggestively associated with CD. Nonetheless, further research is warranted to confirm these findings and to elucidate the underlying mechanisms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1757-1768"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301113/pdf/","citationCount":"0","resultStr":"{\"title\":\"Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.\",\"authors\":\"Chenyang Ge, Yizheng Wang, Xuegang Zhao, Jiawen Hao, Jing Zhang, Mengyuan Lu, Congying Li, Jianke Feng, Qingfu Zhang\",\"doi\":\"10.2147/CCID.S533378\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Research as shown that celiac disease (CD) is associated with skin diseases, but their causality remains unclear. Therefore, this Mendelian randomization (MR) study evaluated the causality between CD and skin diseases.</p><p><strong>Methods: </strong>Bidirectional MR analysis was performed on single nucleotide polymorphism (SNP) candidates identified from genome-wide association study (GWAS) datasets using inverse variance weighted (IVW), weighted median, MR-egger, weighted mode and simple mode. Multivariate MR (MVMR) analysis was subsequently conducted by adjusting for BMI, smoking, and alcohol use. Result reliability was assessed by horizontal pleiotropy and heterogeneity testing.</p><p><strong>Results: </strong>IVW analysis revealed that CD increased the risk of atopic dermatitis (OR = 1.042, 95% CI: 1.018-1.067, <i>P</i> = 5.75 × 10<sup>-4</sup>) and cellulitis (OR = 1.026, 95% CI: 1.006-1.046, <i>P</i> = 9.18×10<sup>-3</sup>). Additionally, psoriasis had a suggestive association with CD (OR=0.836, 95% CI: 0.710-0.983, <i>P</i> = 0.031). MVMR analysis demonstrated that CD had a direct effect on atopic dermatitis and cellulitis.</p><p><strong>Conclusion: </strong>CD contributes to higher risks of atopic dermatitis and cellulitis. Additionally, psoriasis is suggestively associated with CD. Nonetheless, further research is warranted to confirm these findings and to elucidate the underlying mechanisms.</p>\",\"PeriodicalId\":10447,\"journal\":{\"name\":\"Clinical, Cosmetic and Investigational Dermatology\",\"volume\":\"18 \",\"pages\":\"1757-1768\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301113/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical, Cosmetic and Investigational Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CCID.S533378\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical, Cosmetic and Investigational Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CCID.S533378","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：研究表明乳糜泻（CD）与皮肤疾病有关，但其因果关系尚不清楚。因此，这项孟德尔随机化（MR）研究评估了CD与皮肤病之间的因果关系。方法：采用逆方差加权（IVW）、加权中位数、MR-egger、加权模式和简单模式，对从全基因组关联研究（GWAS）数据集中筛选出的候选单核苷酸多态性（SNP）进行双向MR分析。随后通过调整BMI、吸烟和饮酒进行多变量磁共振（MVMR）分析。通过水平多效性和异质性检验评估结果的可靠性。结果：IVW分析显示，CD增加了特应性皮炎（OR = 1.042, 95% CI: 1.018-1.067, P = 5.75 × 10-4）和蜂窝织炎（OR = 1.026, 95% CI: 1.006-1.046, P = 9.18×10-3）的风险。此外，牛皮癣与CD有相关性（OR=0.836, 95% CI: 0.710-0.983, P = 0.031）。MVMR分析表明，CD对特应性皮炎和蜂窝组织炎有直接作用。结论：乳糜泻可增加特应性皮炎和蜂窝组织炎的发病风险。此外，牛皮癣可能与乳糜泻相关。尽管如此，需要进一步的研究来证实这些发现并阐明其潜在的机制。
Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.
Background: Research as shown that celiac disease (CD) is associated with skin diseases, but their causality remains unclear. Therefore, this Mendelian randomization (MR) study evaluated the causality between CD and skin diseases.
Methods: Bidirectional MR analysis was performed on single nucleotide polymorphism (SNP) candidates identified from genome-wide association study (GWAS) datasets using inverse variance weighted (IVW), weighted median, MR-egger, weighted mode and simple mode. Multivariate MR (MVMR) analysis was subsequently conducted by adjusting for BMI, smoking, and alcohol use. Result reliability was assessed by horizontal pleiotropy and heterogeneity testing.
Results: IVW analysis revealed that CD increased the risk of atopic dermatitis (OR = 1.042, 95% CI: 1.018-1.067, P = 5.75 × 10-4) and cellulitis (OR = 1.026, 95% CI: 1.006-1.046, P = 9.18×10-3). Additionally, psoriasis had a suggestive association with CD (OR=0.836, 95% CI: 0.710-0.983, P = 0.031). MVMR analysis demonstrated that CD had a direct effect on atopic dermatitis and cellulitis.
Conclusion: CD contributes to higher risks of atopic dermatitis and cellulitis. Additionally, psoriasis is suggestively associated with CD. Nonetheless, further research is warranted to confirm these findings and to elucidate the underlying mechanisms.
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
