磷酸肌苷作为膜接触位点的调节剂。

IF 3.3 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular and cell biology of lipids Pub Date : 2025-07-26 DOI:10.1016/j.bbalip.2025.159673

Håvard S. Haukaas , Harald Stenmark

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引用次数: 0

摘要

细胞膜接触位点（MCSs）在细胞的脂质、蛋白质和离子转移中起着重要的作用。磷酸肌苷对许多MCS的功能至关重要，无论是作为MCS蛋白的膜锚点，还是作为内质网中磷酸肌苷去磷酸化驱动的反运输机制的一部分。本文综述了磷酸肌苷在内质网与其他细胞器（如质膜、线粒体、核内体、溶酶体、自噬体和高尔基复合体）之间的MCSs中的作用。这些含有磷酸肌醇的MCSs介导Ca2+、磷脂、胆固醇和一种运动蛋白的转移，因此对细胞生理学具有重要意义。

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Phosphoinositides as regulators of membrane contact sites

Membrane contact sites (MCSs) between the different compartments of the cell play important roles in lipid, protein and ion transfer. Phosphoinositides are crucial for the functions of many MCSs, either as membrane anchors for MCS proteins, or as part of a countertransport mechanism driven by phosphoinositide dephosphorylation in the endoplasmic reticulum. Here we review the involvement of phosphoinositides in MCSs between the endoplasmic reticulum and other organelles such as the plasma membrane, mitochondria, endosomes, lysosomes, autophagosomes and the Golgi complex. These phosphoinositide-containing MCSs mediate transfer of Ca2+, phospholipids, cholesterol, and a motor protein, and thus are of great importance for cellular physiology.

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来源期刊

Biochimica et biophysica acta. Molecular and cell biology of lipids 生物-生化与分子生物学

CiteScore

11.00

自引率

2.10%

发文量

109

审稿时长

53 days

期刊介绍： BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.