子叶醇的异源生物合成及密藤二萜的简明合成。

IF 2.1 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-07-21 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.111

Ye Yuan, Zhenhua Guan, Xue-Jie Zhang, Nanyu Yao, Wenling Yuan, Yonghui Zhang, Ying Ye, Zheng Xiang

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引用次数: 0

摘要

报道了一种新的合成fusicoccane二萜的方法。利用花青素和梭菌素的生物合成途径，在一个工程米曲霉菌株中生产了子叶醇。我们进一步以花青素i为原料，通过4 ~ 5个化学步骤，简明地合成了3种花青素二萜类化合物，包括交替花青素E和花青素A、R，这为制备花青素二萜类化合物及其类似物的生物学研究奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids.

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Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids.

A novel strategy for the synthesis of fusicoccane diterpenoids is reported. By harnessing the biosynthetic pathways of brassicicenes and fusicoccins, cotylenol was produced in an engineered Aspergillus oryzae strain. We further achieved the concise synthesis of three fusicoccane diterpenoids, including alterbrassicicene E and brassicicenes A and R in 4 or 5 chemical steps from brassicicene I. This strategy lays the foundation for the preparation of fusicoccane diterpenoids and their analogues for biological studies.

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.