收缩压目标范围时间对左室肥厚的影响。

IF 3.1 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

American Journal of Hypertension Pub Date : 2025-07-24 DOI:10.1093/ajh/hpaf141

Jianjiao Wang, Wen Li, Gui Man, Yang Liu, Siyu Wang, Shouling Wu, Wei Huang

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引用次数: 0

摘要

背景：我们旨在探讨收缩压靶程时间（SBP-TTR）与左心室肥厚（LVH）之间的关系。方法：在2006年至2020年期间，开滦研究的33,818名参与者接受了超声心动图检查，并参加了至少两次健康检查。目标收缩压（SBP）范围分别定义为120-140 mmHg和110-130 mmHg。采用线性插值法计算SBP-TTR。使用泊松回归模型评估120-140 mmHg SBP-TTR和110-130 mmHg SBP-TTR与LVH相关性的相对风险（RR）和95%置信区间（CIs）。结果：当收缩压目标范围定义为120-140mmHg时，在多变量调整模型中，与参考组（SBP- ttr≤25%）相比，75% < SBP- ttr≤100%组LVH风险显著降低（RR: 0.94, 95% CI: 0.89-0.99）。当收缩压目标范围为110 ~ 130mmhg时，与对照组（SBP- ttr≤25%）相比，25%组LVH风险显著降低。结论：SBP- ttr升高与LVH风险降低相关，呈现明显的剂量-反应关系。与120-140 mmHg的SBP-TTR范围相比，将SBP-TTR维持在110-130 mmHg更有效地降低LVH风险。

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The Impact of Time in Target Range for Systolic Blood Pressure on Left Ventricular Hypertrophy.

Background: We aimed to explore the association between systolic blood pressure time-in-target range (SBP-TTR) and left ventricular hypertrophy (LVH).

Methods: A total of 33,818 participants of the Kailuan Study who underwent echocardiography and had participated in at least two health check-ups between 2006 and 2020. The target systolic blood pressure (SBP) ranges are defined as 120-140 mmHg and 110-130 mmHg, respectively. SBP-TTR was calculated by linear interpolation. Poisson regression models were used to assess relative risk (RR) and 95% confidence intervals (CIs) for the associations of 120-140 mmHg SBP-TTR and 110-130 mmHg SBP-TTR with LVH.

Results: When the SBP target range was defined as 120-140mmHg, in multivariable-adjusted models, compared to the reference group (SBP-TTR ≤ 25%), LVH risk was significantly reduced in the 75% < SBP-TTR ≤ 100% group, (RR: 0.94, 95% CI: 0.89-0.99). When the SBP target range was defined as 110-130mmHg, compared to the reference group (SBP-TTR ≤ 25%),there was significantly reduced in LVH risk in the 25%

Conclusions: With increased SBP-TTR associated with a reduced risk of LVH, demonstrating a clear dose-response relationship. Compared to an SBP-TTR range of 120-140 mmHg, maintaining SBP-TTR at 110-130 mmHg more effectively reduces LVH risk.

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来源期刊

American Journal of Hypertension 医学-外周血管病

CiteScore

6.90

自引率

6.20%

发文量

144

审稿时长

3-8 weeks

期刊介绍： The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.