Role of Wound Care in Management of Severe Verrucous Papular Lesions Due to Mpox Infection: A Case Report.

Abstract: The mpox outbreak has continued in the US since 2022. Although most patients with intact immune systems recover from mpox with supportive care, some patients, especially those who are immunocompromised, can develop severe skin manifestations. The role of wound care in severe mpox cases has not yet been firmly established. The authors report a case of a 43-year-old male with untreated HIV infection who developed severe and progressive cutaneous verrucous lesions due to mpox infection. This case required intense wound care, including syringe-based wound irrigation, gentle debridement, hypochlorous acid solution soaking, and topical cidofovir thick application with occlusive dressing application, as well as prolonged antiviral treatments and vaccinia immune globulin.