心肺机械相互作用。从解剖学上详细的动静脉网络模型的见解。

IF 2.7 3区 医学 Q2 BIOPHYSICS
Caterina Dalmaso, Pablo Javier Blanco, Lucas Omar Müller
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引用次数: 0

摘要

我们提出了一个1D-0D模型,将肺力学的0D描述与闭环解剖细节动静脉网络(ADAVN)模型相结合。我们表明,我们的模型可以令人满意地再现在健康年轻男性休息时观察到的一组感兴趣的心血管指数。接下来,我们评估呼吸对心脏性能的影响,以及对不同血管区压力和流量波形的周期性和平均值的影响。特别是,我们的研究结果证实,呼吸具有基本的泵送功能,有助于静脉回流,其作用主要影响动脉侧血流动力学变量的平均值,而在静脉侧,它对波的周期性有显著影响,并在波形构象方面引发复杂的相互作用。此外,我们通过局部敏感性分析评估了模型预测对模型参数变化的敏感性,无论是在呼吸存在还是不存在的情况下,都强调了模型的动脉侧和静脉侧之间的密切关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardiopulmonary mechanical interactions. Insights from an anatomically detailed arterial-venous network model

Cardiopulmonary mechanical interactions. Insights from an anatomically detailed arterial-venous network model

We present a 1D-0D model that couples a 0D description of lung mechanics to the closed-loop Anatomically-Detailed Arterial-Venous Network (ADAVN) model. We show that our model can satisfactorily reproduce a set of cardiovascular indices of interest observed in healthy young males at rest. Next, we assess the impact of respiration on cardiac performance and on the periodicity and average values of pressure and flow waveforms in different vascular districts. In particular, our results confirm that respiration has a fundamental pumping function, which aids venous return, and that its action affects mainly the average of haemodynamic variables on the arterial side, while on the venous side it has a significant effect on wave periodicity and triggers a complex interplay in terms of waveform conformation. Additionally, we assess the sensitivity of model predictions to variations in model parameters through a local sensitivity analysis, both in the presence and absence of respiration, highlighting a strong relationship between the arterial and venous side of the model.

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来源期刊
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology 工程技术-工程:生物医学
CiteScore
7.10
自引率
8.60%
发文量
119
审稿时长
6 months
期刊介绍: Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.
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