Annika Fechner, Carolin Drees, Wolfgang Vautz, Stefanie Sielemann, Ursula Telgheder, Joachim Franzke, Sebastian Brandt
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Seamless analysis of liquid samples by coupling a thermal desorption chip with ion mobility spectrometry
A novel coupling of a miniaturized thermal desorption chip (TDC) with a flexible microtube plasma (FµTP) ionization source and ion mobility spectrometry (IMS) enables direct, solvent-free analysis of a liquid sample. The integrated TDC-FµTP-IMS system combines sample introduction, preconcentration, and time-resolved desorption via adjustable temperature gradients. Quantitative analysis of a ketone mixture demonstrated excellent linearity and detection limits between 34 µg L−1 and 79 µg L−1. In addition, N-hexanoyl homoserine lactone was successfully quantified from a liquid sample without manual preparation. The method provides a fast, sensitive, and selective approach for direct liquid-phase IMS applications.
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Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
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