2004年至2023年全球富血小板血浆再生医学现状的文献计量学分析

IF 3.5 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-07-29 DOI:10.1016/j.reth.2025.07.007

Siwen Zhang , Xudong Zhang , Haochen Zhang , Shengqing Zhang , Zichen Liu , Shanshan Wu , Yimeng Lu , Chao Han , Jichun Tan

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引用次数: 0

摘要

富血小板血浆（PRP）是一种浓缩全血血小板的血浆产品，广泛用于再生医学。本研究旨在评价PRP在再生医学研究现状的演变、发展趋势和研究重点。方法从Web of Science （WoS）的SCIE数据库中检索2024年2月与PRP相关的出版物。影响因子（IF）被用来评价和比较不同国家的贡献。然后，列出了排名前10的国家、排名前10的高产期刊、排名前10的WoS类别和排名前10的被引文章。对数据进行了处理，并以折线图和热图的形式展示了每年产量最高的10个国家的相对贡献。根据关键词的变化趋势，利用VOSviewer软件和热图对研究亮点进行整体趋势调查。结果SCIE数据库共检索文献9577篇。美国以2311篇论文位居榜首，其次是中国（1583篇）、英国（525篇）、西班牙（512篇）。PRP在再生医学领域的研究在全球范围内呈增长趋势。美国的总被引次数最多，相对贡献排名第一，英国的平均被引次数和平均影响因子排名第一。但自2015年以来，中国的贡献呈急剧上升趋势，并在2022年超过了美国。关键词共现分析共生成“骨相关类”、“透明质酸相关类”、“软骨相关类”、“口腔相关类”、“损伤修复相关类”、“实验相关类”、“神经相关类”7个关键词。除了骨头&；在关节疾病方面，PRP的新临床应用已经开展，包括牙科和神经医学、生殖医学、皮肤科、妇科、整形外科、美容治疗以及非肌肉骨骼器官功能的改善。综上所述，PRP在美国和中国的研究进展较为突出。PRP的实验研究多集中在机理和信号通路的探索上。作为一种有效的辅助治疗，PRP的临床应用已经从最初的创伤修复扩展到多系统器官疾病。利用多学科交叉，开发针对特定疾病特征的新型prp医疗材料可能是未来研究的一个有希望的方向。

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A bibliometric analysis of the global status of platelet-rich plasma in regenerative medicine from 2004 to 2023

Introduction

Platelet-rich plasma (PRP) is a plasma product that concentrates platelets from whole blood and used widely in regenerative medicine. This study aimed to evaluate the evolution, development trend, and research highlights of research status of PRP in regenerative medicine.

Methods

Publications related to PRP were retrieved from the Science Citation Index Expanded (SCIE) database of the Web of Science (WoS) in February 2024. The impact factor (IF) was used to evaluate and compare the contributions of different countries. Then, the top 10 countries, top 10 productive journals, top 10 WoS categories, and top 10 most cited articles were listed. The data was processed, and the relative contributions of the top 10 productive countries in each year were presented in a line chart and a heatmap. VOSviewer software and heatmap were used to investigate the holistic trend of research highlights according to the change trends of keywords.

Results

A total of 9,577 publications were retrieved from SCIE database. The USA topped the list with 2,311 papers, followed by China (1,583 papers), the UK (525 papers), and Spain (512 papers). The studies of PRP in regenerative medicine have increasing trend globally. The USA had the most total citation and took the leading position for relative contributions, the UK ranked 1st in average citations and average IF. However, China's contribution had a dramatically increasing trend since 2015, and exceeded the USA in 2022. There were seven keywords of “Bone-related cluster”, “hyaluronic acid-related cluster”, “cartilage-related cluster”, “stomatology-related cluster”, “damage repair-related cluster”, “experiment-related cluster”, and “nerve-related cluster” generated in keyword co-occurrence analysis. Except for bone & joint diseases, novel clinical applications of PRP have been carried out, including dental and neurological practice, reproductive medicine, dermatology, gynecology, and plastic surgery, cosmetic treatments, and the improvement of non-musculoskeletal organ function.

Conclusion

To summarize, the research advancements of PRP appear to be more prominent in the United States and China. Experimental research on PRP is mostly concentrated on exploring on mechanism and signal pathway. As an effective adjuvant treatment, the clinical application of PRP has expanded from initial trauma repair to multiple systemic organ disorders. Leveraging the intersection of multiple disciplines, the development of novel PRP-based medical materials tailored to specific disease characteristics may represent a promising direction for future research.

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.