流式细胞术在多发性骨髓瘤诊断和预后中的应用

IF 3.5 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Seminars in Diagnostic Pathology Pub Date : 2025-07-25 DOI:10.1016/j.semdp.2025.150942

Adam C. Seegmiller

{"title":"流式细胞术在多发性骨髓瘤诊断和预后中的应用","authors":"Adam C. Seegmiller","doi":"10.1016/j.semdp.2025.150942","DOIUrl":null,"url":null,"abstract":"<div><div>Multiparameter flow cytometry is an effective tool in the diagnosis and monitoring of plasma cell neoplasms such as multiple myeloma. This review focuses on how flow cytometry can be used to identify and characterize plasma cells. It discusses the immunophenotype of normal plasma cells and how this can be used to distinguish them from neoplastic plasma cells. The prognostic impact of particular immunophenotypic aberrancies is reviewed. Finally, it describes approaches to post-treatment monitoring myeloma by flow cytometry, including measurable residual disease detection and its impact on disease outcomes.</div></div>","PeriodicalId":49548,"journal":{"name":"Seminars in Diagnostic Pathology","volume":"42 5","pages":"Article 150942"},"PeriodicalIF":3.5000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flow cytometry in the diagnosis and prognosis of multiple myeloma\",\"authors\":\"Adam C. Seegmiller\",\"doi\":\"10.1016/j.semdp.2025.150942\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Multiparameter flow cytometry is an effective tool in the diagnosis and monitoring of plasma cell neoplasms such as multiple myeloma. This review focuses on how flow cytometry can be used to identify and characterize plasma cells. It discusses the immunophenotype of normal plasma cells and how this can be used to distinguish them from neoplastic plasma cells. The prognostic impact of particular immunophenotypic aberrancies is reviewed. Finally, it describes approaches to post-treatment monitoring myeloma by flow cytometry, including measurable residual disease detection and its impact on disease outcomes.</div></div>\",\"PeriodicalId\":49548,\"journal\":{\"name\":\"Seminars in Diagnostic Pathology\",\"volume\":\"42 5\",\"pages\":\"Article 150942\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Diagnostic Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0740257025000784\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Diagnostic Pathology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0740257025000784","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

多参数流式细胞术是诊断和监测多发性骨髓瘤等浆细胞肿瘤的有效工具。本文综述了流式细胞术如何用于鉴定和表征浆细胞。它讨论了正常浆细胞的免疫表型，以及如何用它来区分它们与肿瘤浆细胞。本文回顾了特定免疫表型异常对预后的影响。最后，它描述了通过流式细胞术治疗后监测骨髓瘤的方法，包括可测量的残留疾病检测及其对疾病结局的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Flow cytometry in the diagnosis and prognosis of multiple myeloma

Multiparameter flow cytometry is an effective tool in the diagnosis and monitoring of plasma cell neoplasms such as multiple myeloma. This review focuses on how flow cytometry can be used to identify and characterize plasma cells. It discusses the immunophenotype of normal plasma cells and how this can be used to distinguish them from neoplastic plasma cells. The prognostic impact of particular immunophenotypic aberrancies is reviewed. Finally, it describes approaches to post-treatment monitoring myeloma by flow cytometry, including measurable residual disease detection and its impact on disease outcomes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Seminars in Diagnostic Pathology 医学-病理学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Each issue of Seminars in Diagnostic Pathology offers current, authoritative reviews of topics in diagnostic anatomic pathology. The Seminars is of interest to pathologists, clinical investigators and physicians in practice.