心力衰竭中的心肝轴

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2025-07-01 DOI:10.1016/j.jacbts.2025.05.007

Arick C. Park MD, PhD , Joel D. Schilling MD, PhD

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引用次数: 0

摘要

心源性肝病是右心衰引起的肝充血的后遗症，可导致肝功能障碍和不良的肝脏重塑。了解心衰综合征的肝脏病理机制和后果是慢性心衰患者护理中一个重要的未满足的需求。肝充血引起肝细胞和非实质细胞（包括内皮细胞、巨噬细胞和肝星状细胞）的深刻反应。然而，驱动肝纤维化和功能障碍的途径尚不清楚。最近的人类和临床前数据已经开始揭示定义心源性肝病的细胞景观和分子途径。这篇综述旨在讨论我们目前对心力衰竭中心肝轴的理解，同时也强调了知识差距和未来研究的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Cardiohepatic Axis in Heart Failure

Cardiogenic liver disease is a sequela of hepatic congestion from right heart failure that leads to hepatic dysfunction and adverse liver remodeling. Understanding the mechanisms and consequences of liver pathology in the syndrome of heart failure is an important unmet need in the care of patients with chronic heart failure. Liver congestion provokes profound responses in hepatocytes and nonparenchymal cells including endothelial cells, macrophages, and hepatic stellate cells. However, the pathways that drive liver fibrosis and dysfunction are poorly understood. Recent human and preclinical data has begun to unravel the cellular landscape and molecular pathways that define cardiogenic liver disease. This review aims to discuss our current understanding of the cardiohepatic axis in heart failure while also highlighting knowledge gaps and opportunities for future investigation.

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.