双能谱CT评估多发性骨髓瘤的假定肿瘤体积及其与血液学表现的相关性

IF 2.9 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Open Pub Date : 2025-07-29 DOI:10.1016/j.ejro.2025.100675

Tetsuya Kosaka , Chisaki Masuda , Sachiho Tatebe , Risen Hirai , Akira Tanimura

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引用次数: 0

摘要

目的应用双能谱计算机断层扫描（DESCT）测量多发性骨髓瘤患者肱骨推定肿瘤体积，并评价其与血液学指标的相关性。方法回顾性分析22例多发性骨髓瘤患者的82例DESCT检查结果。在提取双侧肱骨并去除骨组织后，我们使用基于Hounsfield单位值的单阈值和使用材料密度图像的双阈值测量假设肿瘤区域的体积。我们分析了肿瘤体积与血液学指标（β2-微球蛋白、m蛋白、游离轻链、白蛋白、乳酸脱氢酶）的相关性以及治疗干预后的趋势。结果初始扫描假定肿瘤体积与β2微球蛋白水平存在中等相关性，单霍斯菲尔德单位阈值计算的体积相关系数为ρ = 0.69，双骨（脂肪）物质密度图像阈值计算的体积相关系数为ρ = 0.57。假设的肿瘤体积与m蛋白或游离轻链水平之间没有明显的相关性。在初始检查后接受三次或三次以上随访评估的患者中，治疗后假定肿瘤体积和β2微球蛋白水平的变化相似。结论利用DESCT提取假定肿瘤体积作为多发性骨髓瘤的生物标志物具有足够的潜力。

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Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings

Objectives

To measure the assumed tumour volume in the humerus of patients with multiple myeloma using dual-energy spectral computed tomography (DESCT) and to evaluate the correlation with haematological indicators.

Methods

We retrospectively analysed 82 DESCT examinations of 22 patients diagnosed with multiple myeloma. After extracting the bilateral humeri and removing the bone tissue, we measured the volume of the assumed tumour area using a single threshold based on Hounsfield unit values and double thresholds using material density images. We analysed the correlations between tumour volume and haematological indicators (β2-microglobulin, M-protein, free light chain, albumin, lactate dehydrogenase) and the trends after treatment intervention.

Results

A moderate correlation was identified between the assumed tumour volume in the initial scan and the β2-microglobulin level, with a correlation coefficient of ρ = 0.69 for the volume calculated from a single threshold value of Hounsfield unit and ρ = 0.57 for the volume calculated from a double threshold value of the bone(fat) material density image. No significant correlation was found between the assumed tumour volume and the M-protein or free light chain levels. In patients who underwent three or more follow-up evaluations after the initial examination, there was a similarity in the changes in the assumed tumour volume and β2-microglobulin levels after treatment.