卵黄林巴的生物活性成分作为潜在的体外hSGLT2抑制剂

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-07-25 DOI:10.1016/j.phytochem.2025.114626

Zhi-Yong Jiang , Lin Chen , Hong-Xi Xie , Jun-Jie Hao , Rong Chen , Chun-Qiu Huang , Hong-Lei Zhang , Ai-Xue Zuo

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引用次数: 0

摘要

从卵凤蝶中分离得到16个化合物，其中12个为未见的倍半萜类化合物。基于hresms、IR、NMR和电子圆二色性（ECD）光谱分析，鉴定了上述化合物为12个未描述的二氢-β-琼脂呋喃倍半萜类化合物（化合物1 ~ 12）。化合物1和6的结构经单晶x射线衍射证实。结果表明，化合物11和13具有明显的hSGLT2抑制活性，IC50值分别为11.9和9.45 nM。通过精确的蛋白质-配体复合物模型进行分子对接，预测了可能的结合效力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bioactive constituents from Salacia obovatilimba as potential in vitro hSGLT2 inhibitors

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Bioactive constituents from Salacia obovatilimba as potential in vitro hSGLT2 inhibitors

Sixteen compounds including twelve previously undescribed sesquiterpenes were isolated from Salacia obovatilimba. Based on HRESIMS, IR, NMR and electronic circular dichroism (ECD) spectroscopic analysis, the previously undescribed compounds were characterized as twelve undescribed dihydro-β-agarofuran sesquiterpenoids (compounds 1–12). The structures of compounds 1 and 6 were confirmed by single-crystal X-ray diffraction. All compounds were assayed for their inhibitory effect on hSGLT2 in vitro, results suggested compounds 11 and 13 exhibited significant hSGLT2 inhibitory activity, with IC₅₀ values of 11.9 and 9.45 nM, respectively. The probable binding potency were predicted through molecular docking by accurate models of protein-ligand complex.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.