通过调节O2浓度选择性合成甲基取代和无甲基n -杂环。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-07-27 DOI:10.1021/acs.joc.5c01331

Chengcheng Ding,Xiaoyang Gao,Yimo Zhao,Kaili Feng,Yunkai Zhang,Chen Ma

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引用次数: 0

摘要

本文提出了一种通过调节氧浓度选择性合成甲基取代和无甲基n -杂环化合物的方法。这种选择性是通过引导碳合成子在反应中充当C1或C2合成子来实现的。该过程不需要任何额外的溶剂，并且醚与该转换相容。通过详细的控制实验来阐明这种选择性转化的原因，并提出了一种可能的反应机理。通过产品功能化成生物活性化合物和克级实验，证明了该方法的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Selective Synthesis of Methyl-Substituted and Methyl-Free N-Heterocycles via Modulation of O2 Concentration.

Herein, we present a method for the selective synthesis of methyl-substituted and methyl-free N-heterocyclic compounds by adjusting the O2 concentration. This selectivity is achieved by directing the carbon synthons to act as either C1 or C2 synthons in the reaction. The process does not require any additional solvents, and ethers are compatible with this conversion. Detailed control experiments were conducted to elucidate the reason for this selective conversion, and a possible reaction mechanism is proposed. The application value of the method is demonstrated through the functionalization of the products into biologically active compounds and gram-scale experiments.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.