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单分子力谱法直接测定SARS-CoV-2刺突RBD与整合素αvβ6的结合

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Chemical Communications Pub Date : 2025-07-29 DOI:10.1039/d5cc03034j
Tianfu Feng, Fang Tian, Jiamin Li, Xianchi Dong, Bei Tong, Peng Zheng
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引用次数: 0

摘要

单分子力谱显示，SARS-CoV-2 RBD与整合素αvβ6之间存在强的阳离子依赖性结合，破裂力超过ACE2，支持整合素αvβ6作为替代受体。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Direct Measurement of SARS-CoV-2 Spike RBD Binding to Integrin αvβ6 by Single-Molecule Force Spectroscopy
Single-molecule force spectroscopy reveals strong, cation-dependent binding between SARS-CoV-2 RBD and integrin αvβ6, with rupture forces exceeding ACE2, supporting integrin αvβ6 as an alternative receptor.
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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