Ya-Xin Li, Dong-Mei Ma, Ming-Xia Wang, Cheng Wang, Fu-Fa Wu, Rong-Da Zhao, Jun Xiang, Xing-Ming Zhao, Tian-Lin Wang
{"title":"异质结构COF/TiO 2 /MWCNT-COOH复合传感器用于多巴胺和尿酸的同时和单独电化学检测","authors":"Ya-Xin Li, Dong-Mei Ma, Ming-Xia Wang, Cheng Wang, Fu-Fa Wu, Rong-Da Zhao, Jun Xiang, Xing-Ming Zhao, Tian-Lin Wang","doi":"10.1016/j.jallcom.2025.182602","DOIUrl":null,"url":null,"abstract":"In this study, we employed an innovative strategy to construct a heterostructured composite material by integrating a bifunctional covalent organic framework (COF), nano-titanium dioxide (TiO<sub>2</sub>), and carboxylated multi-walled carbon nanotubes (MWCNT-COOH). Through strong chemical bonding interactions, TiO<sub>2</sub> and MWCNT-COOH were successfully anchored onto the COF, resulting in the formation of a COF/TiO<sub>2</sub>/MWCNT-COOH heterojunction composite. This composite was subsequently applied for the highly sensitive and selective detection of dopamine (DA) and uric acid (UA). The bifunctional COF, synthesized via imine bond formation, possesses a large specific surface area. Under the catalytic influence of TiO<sub>2</sub>, the composite material exposes additional active sites, thereby facilitating an efficient two-electron transfer process for the biomolecules transported by MWCNT-COOH. The synergistic interactions among the COF, TiO<sub>2</sub>, and MWCNT-COOH significantly enhance the biosensor's analytical performance, particularly in terms of adsorption and enrichment of DA and UA. Experimental results reveal that the fabricated electrochemical biosensor achieves an impressively low limit of detection (LOD) of 0.0236<!-- --> <!-- -->μM for DA, with a linear detection range of 0.3<!-- --> <!-- -->μM to 500<!-- --> <!-- -->μM. For UA, the LOD is 0.0829<!-- --> <!-- -->μM, with a linear range from 0.1<!-- --> <!-- -->μM to 800<!-- --> <!-- -->μM. Moreover, the biosensor demonstrates excellent selectivity, reproducibility, strong anti-interference capabilities, and long-term stability, highlighting its significant potential for practical applications in electrochemical biosensing.","PeriodicalId":344,"journal":{"name":"Journal of Alloys and Compounds","volume":"718 1","pages":""},"PeriodicalIF":6.3000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Heterostructured COF/TiO₂/MWCNT-COOH composite sensor for simultaneous and individual electrochemical detection of dopamine and uric acid\",\"authors\":\"Ya-Xin Li, Dong-Mei Ma, Ming-Xia Wang, Cheng Wang, Fu-Fa Wu, Rong-Da Zhao, Jun Xiang, Xing-Ming Zhao, Tian-Lin Wang\",\"doi\":\"10.1016/j.jallcom.2025.182602\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, we employed an innovative strategy to construct a heterostructured composite material by integrating a bifunctional covalent organic framework (COF), nano-titanium dioxide (TiO<sub>2</sub>), and carboxylated multi-walled carbon nanotubes (MWCNT-COOH). Through strong chemical bonding interactions, TiO<sub>2</sub> and MWCNT-COOH were successfully anchored onto the COF, resulting in the formation of a COF/TiO<sub>2</sub>/MWCNT-COOH heterojunction composite. This composite was subsequently applied for the highly sensitive and selective detection of dopamine (DA) and uric acid (UA). The bifunctional COF, synthesized via imine bond formation, possesses a large specific surface area. Under the catalytic influence of TiO<sub>2</sub>, the composite material exposes additional active sites, thereby facilitating an efficient two-electron transfer process for the biomolecules transported by MWCNT-COOH. The synergistic interactions among the COF, TiO<sub>2</sub>, and MWCNT-COOH significantly enhance the biosensor's analytical performance, particularly in terms of adsorption and enrichment of DA and UA. Experimental results reveal that the fabricated electrochemical biosensor achieves an impressively low limit of detection (LOD) of 0.0236<!-- --> <!-- -->μM for DA, with a linear detection range of 0.3<!-- --> <!-- -->μM to 500<!-- --> <!-- -->μM. For UA, the LOD is 0.0829<!-- --> <!-- -->μM, with a linear range from 0.1<!-- --> <!-- -->μM to 800<!-- --> <!-- -->μM. Moreover, the biosensor demonstrates excellent selectivity, reproducibility, strong anti-interference capabilities, and long-term stability, highlighting its significant potential for practical applications in electrochemical biosensing.\",\"PeriodicalId\":344,\"journal\":{\"name\":\"Journal of Alloys and Compounds\",\"volume\":\"718 1\",\"pages\":\"\"},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alloys and Compounds\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jallcom.2025.182602\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alloys and Compounds","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1016/j.jallcom.2025.182602","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Heterostructured COF/TiO₂/MWCNT-COOH composite sensor for simultaneous and individual electrochemical detection of dopamine and uric acid
In this study, we employed an innovative strategy to construct a heterostructured composite material by integrating a bifunctional covalent organic framework (COF), nano-titanium dioxide (TiO2), and carboxylated multi-walled carbon nanotubes (MWCNT-COOH). Through strong chemical bonding interactions, TiO2 and MWCNT-COOH were successfully anchored onto the COF, resulting in the formation of a COF/TiO2/MWCNT-COOH heterojunction composite. This composite was subsequently applied for the highly sensitive and selective detection of dopamine (DA) and uric acid (UA). The bifunctional COF, synthesized via imine bond formation, possesses a large specific surface area. Under the catalytic influence of TiO2, the composite material exposes additional active sites, thereby facilitating an efficient two-electron transfer process for the biomolecules transported by MWCNT-COOH. The synergistic interactions among the COF, TiO2, and MWCNT-COOH significantly enhance the biosensor's analytical performance, particularly in terms of adsorption and enrichment of DA and UA. Experimental results reveal that the fabricated electrochemical biosensor achieves an impressively low limit of detection (LOD) of 0.0236 μM for DA, with a linear detection range of 0.3 μM to 500 μM. For UA, the LOD is 0.0829 μM, with a linear range from 0.1 μM to 800 μM. Moreover, the biosensor demonstrates excellent selectivity, reproducibility, strong anti-interference capabilities, and long-term stability, highlighting its significant potential for practical applications in electrochemical biosensing.
期刊介绍:
The Journal of Alloys and Compounds is intended to serve as an international medium for the publication of work on solid materials comprising compounds as well as alloys. Its great strength lies in the diversity of discipline which it encompasses, drawing together results from materials science, solid-state chemistry and physics.