尿毒症毒素、肠道菌群和饮食之间的复杂相互作用

IF 39.8 1区 医学 Q1 UROLOGY & NEPHROLOGY
Monica Wang
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引用次数: 0

摘要

肠道源性尿毒毒素(ut)是慢性肾脏疾病(CKD)病理生理的关键因素。现在,桑德拉·瓦格纳和他的同事报告了ckd相关的肠道微生物群的纵向变化和营养的影响。CKD参与者的eGFR平均每年下降1.4 ml/min/1.73m2,在2.8年的随访中,他们的粪便样本显示细菌种类丰富度下降。随着CKD的进展,产生ut的细菌种类相对于检测到的总细菌种类的丰度也增加,但这一指标受到饮食的影响。在增加蔬菜摄入量、减少蛋白质摄入量或食用益生菌的参与者中,产生ut的物种减少了,而在减少纤维摄入量的参与者中,产生ut的物种增加了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Complex interplay between uraemic toxins, gut microbiota and diet

Complex interplay between uraemic toxins, gut microbiota and diet
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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