对欧亚大陆野猪的人口历史和当地适应的基因组见解。

IF 11.1 Q1 CELL BIOLOGY
Zishuai Wang, Zixin Li, Tao Huang, Jianhai Chen, Pan Xu, Ruimin Qiao, Hongwei Yin, Chengyi Song, Dongjie Zhang, Di Liu, Shuhong Zhao, Martien A M Groenen, Ole Madsen, Yanlin Zhang, Lijing Bai, Kui Li
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引用次数: 0

摘要

野猪表现出由迁徙和当地适应形成的遗传和表型多样性。它们在欧亚大陆的扩张,尤其是在中亚的扩张,仍未得到充分探索。在这里,我们展示了来自东亚、中亚和欧洲的47只野猪的新测序全基因组数据,并结合49个现有基因组,创建了一个包含96个个体的综合数据集。我们的分析表明,亚洲野猪和东南亚野猪在大约360万年前(mya)分裂,中亚和中国南方的祖先在大约180万年前分化。中亚祖先和欧洲-近东祖先之间的分裂发生在约0.9亿年前,随后是欧洲-近东祖先的分裂发生在约0.6亿年前。我们在中亚人群中发现了局部适应的特征,包括两个与脂质代谢相关的LPIN1正选择变异,以及一个与肉类性状相关的ALPK2错义突变。这些发现为野猪的扩散和适应提供了见解,并为家猪育种提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genomic insights into the demographic history and local adaptation of wild boars across Eurasia.

Wild boars exhibit genetic and phenotypic diversity shaped by migrations and local adaptations. Their expansion across Eurasia, especially in Central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild boars from Eastern Asia, Central Asia, and Europe, combined with 49 existing genomes, creating a comprehensive dataset of 96 individuals. Our analyses show that Asian wild boars and Southeast Asian Suids split ∼3.6 million years ago (mya), with Central Asian and Southern Chinese ancestors diverging ∼1.8 mya. The split between Central Asian and European-Near East ancestors occurred ∼0.9 mya, followed by a European-Near East divergence ∼0.6 mya. We identify signatures of local adaptation in Central Asian populations, including two positively selected variants in LPIN1, associated with lipid metabolism, and a missense mutation in ALPK2, linked to meat traits. These findings provide insights into wild boar dispersal and adaptation and shed light on domestic pig breeding.

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