Cell genomics

Detecting low-allele-fraction mosaic mutations: A multi-institution benchmarking with cell-line mixtures.

Pub Date : 2026-10-15 DOI: 10.1016/j.xgen.2026.101390 Yoo-Jin Jiny Ha, Dominika Maziec, Julia Markowski, Stephanie J Georges, Nancy L Parmalee, Michele Berselli, Tim H H Coorens, Shihua Dong, Stephanie Gardiner, Divya Kalra, Daofeng Li, Benpeng Miao, Rajeeva Musunuri, Liying Xue, Zhi Yu, Kimberly Walker, Lisa Anderson, Natalie Y T Au, Carrie Cibulskis, Harsha Doddapaneni, Christopher M Grochowski, Dana M Jensen, Tina Lindsay, Kelsey Loy, Azeet Narayan, Giuseppe Narzisi, Jeffrey Ou, Meranda M Pham, Alexi M Runnels, Andrew B Stergachis, Lila M Sutherlin, Ting Wang, Hu Jin, William C Feng, Yuwei Zhang, Alexander D Veit, Clara TaeHee Kim, Hye-Jung E Chun, Kristin Ardlie, Robert S Fulton, Soren Germer, Richard A Gibbs, Gabor T Marth, James T Bennett, Peter J Park

NeoBridge: Biophysics-informed neoantigen prioritization and clonal architecture profiling in pancreatic cancer.

Pub Date : 2026-10-15 DOI: 10.1016/j.xgen.2026.101397 Alejandro Lana Mediavilla, Javier Pérez Cardoso, Jaime Álvarez-Benayas, Víctor Javier Sánchez-Arévalo Lobo

A pangenomic method for establishing a synthetic somatic variant resource in HapMap mixtures.

Pub Date : 2026-10-15 DOI: 10.1016/j.xgen.2026.101358 Nahyun Kong, Zitian Tang, Andrew Ruttenberg, Juan F Macias-Velasco, Zefan Li, Emma Casey, Wenjin Zhang, Benpeng Miao, Zilan Xin, Qichen Fu, Haeorum Park, Xiaoyu Zhuo, Elvisa Mehinovic, Edward Belter, Chad Tomlinson, John E Garza, Shihua Dong, Ben Johnson, Mary F Majewski, Theron Palmer, Yuchen Cheng, Tina Lindsay, Tim Schedl, Daofeng Li, Hui Shen, Robert Fulton, Ting Wang, Sheng Chih Jin