亚洲人、夏威夷原住民和其他太平洋岛民患者与白人患者宫颈癌诊断阶段和生存结果的差异

IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Zhenyu Ma, Mei Liu, Qipeng Yuan, Ziniu Tang, Peng Shang, Chen Wang, Yueze Li, Jinbo Yue
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引用次数: 0

摘要

目的:探讨亚洲患者与夏威夷原住民和其他太平洋岛民(NHPIs)宫颈癌诊断和预后的差异。方法:我们从监测、流行病学和最终结果17数据库中提取宫颈癌患者数据。分别使用逻辑回归和加速失效时间模型估计生存结果的分期比值比(ORs)和时间比值比(TRs)。结果:18770例患者中,15847例(84.4%)为白种人;2618人(13.9%)为亚洲人;NHPI 305例(1.6%)。NHPI患者早期被诊断的可能性低于White患者(调整OR [aOR]: 0.60;95% CI, 0.47-0.77),而亚裔患者的诊断分期与白人患者相似(aOR: 0.93;95% ci, 0.85-1.02)。作为一个群体,亚洲患者的总生存期(OS)明显更长(调整后TR [aTR]: 1.46;95% CI, 1.33-1.61)和疾病特异性生存(DSS) (aTR: 1.35;95% CI(1.21-1.51)高于白人患者;nhpi则相反(OS: aTR, 0.80;95% ci, 0.64-1.00;DSS: aTR, 0.75;95% ci, 0.59-0.97)。结论:我们发现NHPI宫颈癌患者在病程中比白人患者诊断较晚,诊断后生存时间较短,而亚裔患者生存时间较长。这些发现支持子宫颈癌调查中亚洲和非印度裔人种的分类。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differences in cervical cancer stage at diagnosis and survival outcomes among Asian, Native Hawaiian, and other Pacific Islander patients and White patients.

Purpose: To explore disparities in cervical cancer diagnosis and outcomes for Asian patients and Native Hawaiian and other Pacific Islanders (NHPIs).

Methods: We extracted cervical cancer patient data collected from the Surveillance, Epidemiology, and End Results 17 database. Odds ratios (ORs) for stage and time ratios (TRs) for survival outcomes were estimated using logistic regression and accelerated failure time models, respectively.

Results: Of 18770 patients, 15,847 (84.4 %) were White; 2618 (13.9 %) were Asian; and 305 (1.6 %) were NHPI. NHPI patients were less likely than White patients to be diagnosed at an early stage (adjusted OR [aOR]: 0.60; 95 % CI, 0.47-0.77), whereas Asian patients had similar stage-at-diagnosis to White patients (aOR: 0.93; 95 % CI, 0.85-1.02). Asian patients, as a group, had significantly longer overall survival (OS) (adjusted TR [aTR]: 1.46; 95 % CI, 1.33-1.61) and disease-specific survival (DSS) (aTR: 1.35; 95 % CI, 1.21-1.51) than White patients; the opposite was true for NHPIs (OS: aTR, 0.80; 95 % CI, 0.64-1.00; DSS: aTR, 0.75; 95 % CI, 0.59-0.97).

Conclusions: We find that NHPI cervical cancer patients tend to be diagnosed later in their disease course than White patients and have shorter survival time post-diagnosis, while Asian patients tend to have longer survival time. These findings support the disaggregation of Asian and NHPI races in cervical cancer investigations.

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来源期刊
Annals of Epidemiology
Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.40
自引率
1.80%
发文量
207
审稿时长
59 days
期刊介绍: The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.
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