协调组织发育以构建身体和大脑:来自原肠腺组织者及其衍生物的教训。

IF 2 4区 生物学 Q3 DEVELOPMENTAL BIOLOGY
Alexandra Neaverson, Benjamin Steventon
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引用次数: 0

摘要

一个多世纪以来,Spemann-Mangold组织者一直是发育生物学的中心范式,主要通过其在移植实验中诱导次级轴的能力进行研究。然而,组织者及其衍生物如何共同作用以产生匀称的身体轴仍是未知的。在这里,我们回顾了四种主要脊椎动物模型(爪蟾、斑马鱼、小鸡和老鼠)的证据,以评估组织者在神经发育和身体轴形成方面的阶段特异性要求。我们提出了一个共识的观点,即最初的神经规范和前后模式发生在形态组织者形成之前,由来自前组织者细胞的平面信号和来自胚胎外组织的物种特异性贡献驱动。我们还讨论了组织者衍生的前轴中胚层(脊索前板和头突)如何主要通过持续的信号传导维持前轴身份并确保适当的组织比例。后组织者衍生物脊索对背-腹侧神经模式仍然至关重要,但也通过与邻近组织的机械耦合协调后体延伸,轴向中胚层延伸的速度是比例体轴发育的关键协调者。未来的研究将提高我们对组织者衍生物在轴形成过程中如何协调多个组织的机械和分子协调的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coordinating tissue development to build body and brain: Lessons from the gastrula organiser and its derivatives.

The Spemann-Mangold organiser has been a central paradigm in developmental biology for over a century, primarily studied through its ability to induce secondary axes in transplantation experiments. However, how the organiser and its derivatives act together to generate a well-proportioned body axis is still unknown. Here, we review evidence across four major vertebrate models (Xenopus, zebrafish, chick, and mouse) to evaluate the organiser's stage-specific requirements in neural development and body axis formation. We present a consensus view that initial neural specification and anterior-posterior patterning occur before morphological organiser formation, driven by planar signals from pre-organiser cells and species-specific contributions from extraembryonic tissues. We also discuss how the organiser-derived anterior axial mesendoderm (prechordal plate and head process) primarily acts to maintain anterior identity and ensure proper tissue proportions through continued signalling. The posterior organiser derivative, the notochord, remains essential for dorsal-ventral neural patterning, but also coordinates posterior body elongation through mechanical coupling with adjacent tissues, and the pace of axial mesoderm extension serves as a key coordinator of proportional body axis development. Future studies will improve our understanding of how organiser derivatives orchestrate the mechanical and molecular coordination of multiple tissues during axis formation.

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来源期刊
Cells & Development
Cells & Development DEVELOPMENTAL BIOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
33
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