可见光照射下胶体CdS颗粒光催化氧化酪氨酸的研究。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Pratigya Rizal, Devendra P S Negi
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引用次数: 0

摘要

生物体中酪氨酸的酶催化氧化导致多巴胺的形成,多巴胺是黑素形成途径的关键中间体。因此,本文对酪氨酸光催化氧化合成多巴胺的研究具有重要意义。据我们所知,这是利用半导体粒子从酪氨酸形成多巴胺的第一份报告。本文合成了CdS胶体颗粒,并用x射线衍射仪(XRD)和透射电镜(TEM)对其进行了表征。将含有1 mM酪氨酸和胶体CdS颗粒的反应混合物在可见光存在下照射,导致电子光谱紫外区和可见光区的吸收增加。这表明了酪氨酸氧化产物的形成。通过液相色谱-质谱分析,确定了酪氨酸氧化产物为二酪氨酸和多巴铬。提出了两种光产物形成的可能反应机理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Photocatalytic oxidation of tyrosine using colloidal CdS particles under visible light irradiation.

Photocatalytic oxidation of tyrosine using colloidal CdS particles under visible light irradiation.

Photocatalytic oxidation of tyrosine using colloidal CdS particles under visible light irradiation.

Photocatalytic oxidation of tyrosine using colloidal CdS particles under visible light irradiation.

The enzyme-catalyzed oxidation of tyrosine in living organisms leads to the formation of dopachrome which is a key intermediate in the melanogenesis pathway. Therefore, the present manuscript which describes the photocatalytic oxidation of tyrosine to dopachrome is significant. To the best of our knowledge, this is the first report on the use of semiconductor particles for the formation of dopachrome from tyrosine. In the present work, colloidal CdS particles were synthesized and characterized by X-ray diffraction (XRD) measurements and transmission electron microscopy (TEM). The irradiation of the reaction mixture containing 1 mM tyrosine and colloidal CdS particles in the presence of visible light resulted in an increase in the absorption in ultraviolet and visible region of the electronic spectrum. It suggested the formation of the products of the oxidation of tyrosine. Dityrosine and dopachrome were identified as the oxidation products of tyrosine based on the liquid chromatography-mass spectrometry (LC-MS) analysis. The probable reaction mechanisms were proposed for the formation of both the photoproducts.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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