同居人群的严重播散性感染：属于CC398克隆复合体的甲氧西林敏感金黄色葡萄球菌（MSSA）分离物的基因型描述

IF 2.1 4区生物学 Q4 MICROBIOLOGY

Revista Argentina de microbiologia Pub Date : 2025-07-24 DOI:10.1016/j.ram.2025.06.003

Lucía Rago, Gabriela Rubinstein, Carlos Federico Spinelli, María Sol Haim, Tomás Poklépovich Caride, Sabrina Di Gregorio, Marta Mollerach

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引用次数: 0

摘要

在这项研究中，我们描述了两个密切相关的病例多灶MSSA感染在同一家庭。两例患者感染传播严重，但均未出现心内膜炎。所有分离株均对红霉素和克林霉素耐药（诱导型大环内酯耐药表型，iMLSb）。其中一个分离株的基因组分析表明，它属于人类相关的CC398-MSSA克隆复合体，这是我们地区一个新兴的谱系。全基因组测序使该克隆与家畜相关的CC398-MSSA谱系进行了表征和分化。

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Severe disseminated nfections in cohabiting people: Genotypic description of methicillin-susceptible Staphylococcus aureus (MSSA) isolate belonging to CC398 clonal complex.

In this study, we describe two closely related cases of multifocal MSSA infections within the same household. The dissemination of infection was severe in both cases, but none of the patients presented endocarditis. All isolates shared resistance to erythromycin and clindamycin (inducible macrolide resistance phenotype, iMLSb). The genomic analysis of one of the isolates indicated that it belongs to the human-associated CC398-MSSA clonal complex, an emerging lineage in our region. Whole genome sequencing enabled the characterization and differentiation of this clone from the livestock-associated CC398-MSSA lineage.

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来源期刊

Revista Argentina de microbiologia MICROBIOLOGY-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： La Revista Argentina de Microbiología es una publicación trimestral editada por la Asociación Argentina de Microbiología y destinada a la difusión de trabajos científicos en las distintas áreas de la Microbiología. La Asociación Argentina de Microbiología se reserva los derechos de propiedad y reproducción del material aceptado y publicado.