Diane Wilson, Sara Breitbart, Lee DiFonzo, Edmond Kelly, Yenge Diambomba, Dilkash Kajal, Kamini Raghuram, Sabrina Wong, Eugene Ng, Paige Church, Elizabeth Asztalos, Phyllis Glanc, Mehmet Cizmeci, Rosanna Pais, Jeffery Traubici, Lara M Leijser, Steven P Miller, Abhaya V Kulkarni, Linh G Ly
{"title":"早产儿出血性室性扩张早期干预策略的实施。","authors":"Diane Wilson, Sara Breitbart, Lee DiFonzo, Edmond Kelly, Yenge Diambomba, Dilkash Kajal, Kamini Raghuram, Sabrina Wong, Eugene Ng, Paige Church, Elizabeth Asztalos, Phyllis Glanc, Mehmet Cizmeci, Rosanna Pais, Jeffery Traubici, Lara M Leijser, Steven P Miller, Abhaya V Kulkarni, Linh G Ly","doi":"10.1038/s41372-025-02371-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Evaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks' gestation.</p><p><strong>Study design: </strong>Retrospective, multi-center, observational study.</p><p><strong>Results: </strong>One hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (n = 23, 60%); LP and ventricular access device (VAD) only (n = 6, 16%); LP, VAD, ventricular-peritoneal shunt (n = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (p > 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (p < 0.05).</p><p><strong>Conclusion: </strong>Initiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Implementation of an early intervention strategy for post hemorrhagic ventricular dilatation in preterm infants.\",\"authors\":\"Diane Wilson, Sara Breitbart, Lee DiFonzo, Edmond Kelly, Yenge Diambomba, Dilkash Kajal, Kamini Raghuram, Sabrina Wong, Eugene Ng, Paige Church, Elizabeth Asztalos, Phyllis Glanc, Mehmet Cizmeci, Rosanna Pais, Jeffery Traubici, Lara M Leijser, Steven P Miller, Abhaya V Kulkarni, Linh G Ly\",\"doi\":\"10.1038/s41372-025-02371-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Evaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks' gestation.</p><p><strong>Study design: </strong>Retrospective, multi-center, observational study.</p><p><strong>Results: </strong>One hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (n = 23, 60%); LP and ventricular access device (VAD) only (n = 6, 16%); LP, VAD, ventricular-peritoneal shunt (n = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (p > 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (p < 0.05).</p><p><strong>Conclusion: </strong>Initiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.</p>\",\"PeriodicalId\":16690,\"journal\":{\"name\":\"Journal of Perinatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Perinatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41372-025-02371-5\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41372-025-02371-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Implementation of an early intervention strategy for post hemorrhagic ventricular dilatation in preterm infants.
Objective: Evaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks' gestation.
Study design: Retrospective, multi-center, observational study.
Results: One hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (n = 23, 60%); LP and ventricular access device (VAD) only (n = 6, 16%); LP, VAD, ventricular-peritoneal shunt (n = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (p > 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (p < 0.05).
Conclusion: Initiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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