Xue-Li Wang, Lei Cao, Yan-Wen Wang, Ti Chu, Yong-Qi Fan, Yu-Hang Chen, Yi Zhang, Wei-Rong Si, Qi-Ying Jiang, Dong-Dong Wu
{"title":"3-巯基丙酮酸硫转移酶在癌症中的作用。","authors":"Xue-Li Wang, Lei Cao, Yan-Wen Wang, Ti Chu, Yong-Qi Fan, Yu-Hang Chen, Yi Zhang, Wei-Rong Si, Qi-Ying Jiang, Dong-Dong Wu","doi":"10.1016/j.cellsig.2025.112020","DOIUrl":null,"url":null,"abstract":"<p><p>The enzyme 3-Mercaptopyruvate sulfurtransferase (3-MST) is widely present across different biological entities and is essential for the production of hydrogen sulfide (H₂S). This enzyme functions both in the cytosol and mitochondria, and 3-MST mediates the reaction of 3-Mercaptopyruvate (3-MP) with dihydrolipoic acid and thioredoxin to produce hydrogen sulfide. In addition to 3-MST, H₂S can also be produced through the actions of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). H₂S, a gaseous signaling molecule with therapeutic potential, has been found to have therapeutic and alleviating effects on various diseases, including cancer, cardiovascular disease, and neurological disorders. While the roles of CBS and CSE in cancer have been extensively studied and well-described, relatively little information is available in the scientific literature regarding the function and importance of 3-MST in cancer. This article focuses on the role of 3-MST in breast cancer, lung cancer, bladder cancer, and colon cancer, emphasizing its potential as a therapeutic target.</p>","PeriodicalId":9902,"journal":{"name":"Cellular signalling","volume":" ","pages":"112020"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of 3-mercaptopyruvate sulfurtransferase in cancer.\",\"authors\":\"Xue-Li Wang, Lei Cao, Yan-Wen Wang, Ti Chu, Yong-Qi Fan, Yu-Hang Chen, Yi Zhang, Wei-Rong Si, Qi-Ying Jiang, Dong-Dong Wu\",\"doi\":\"10.1016/j.cellsig.2025.112020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The enzyme 3-Mercaptopyruvate sulfurtransferase (3-MST) is widely present across different biological entities and is essential for the production of hydrogen sulfide (H₂S). This enzyme functions both in the cytosol and mitochondria, and 3-MST mediates the reaction of 3-Mercaptopyruvate (3-MP) with dihydrolipoic acid and thioredoxin to produce hydrogen sulfide. In addition to 3-MST, H₂S can also be produced through the actions of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). H₂S, a gaseous signaling molecule with therapeutic potential, has been found to have therapeutic and alleviating effects on various diseases, including cancer, cardiovascular disease, and neurological disorders. While the roles of CBS and CSE in cancer have been extensively studied and well-described, relatively little information is available in the scientific literature regarding the function and importance of 3-MST in cancer. This article focuses on the role of 3-MST in breast cancer, lung cancer, bladder cancer, and colon cancer, emphasizing its potential as a therapeutic target.</p>\",\"PeriodicalId\":9902,\"journal\":{\"name\":\"Cellular signalling\",\"volume\":\" \",\"pages\":\"112020\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellular signalling\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cellsig.2025.112020\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular signalling","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cellsig.2025.112020","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Role of 3-mercaptopyruvate sulfurtransferase in cancer.
The enzyme 3-Mercaptopyruvate sulfurtransferase (3-MST) is widely present across different biological entities and is essential for the production of hydrogen sulfide (H₂S). This enzyme functions both in the cytosol and mitochondria, and 3-MST mediates the reaction of 3-Mercaptopyruvate (3-MP) with dihydrolipoic acid and thioredoxin to produce hydrogen sulfide. In addition to 3-MST, H₂S can also be produced through the actions of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). H₂S, a gaseous signaling molecule with therapeutic potential, has been found to have therapeutic and alleviating effects on various diseases, including cancer, cardiovascular disease, and neurological disorders. While the roles of CBS and CSE in cancer have been extensively studied and well-described, relatively little information is available in the scientific literature regarding the function and importance of 3-MST in cancer. This article focuses on the role of 3-MST in breast cancer, lung cancer, bladder cancer, and colon cancer, emphasizing its potential as a therapeutic target.
期刊介绍:
Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo.
Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.