3-巯基丙酮酸硫转移酶在癌症中的作用。

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
Xue-Li Wang, Lei Cao, Yan-Wen Wang, Ti Chu, Yong-Qi Fan, Yu-Hang Chen, Yi Zhang, Wei-Rong Si, Qi-Ying Jiang, Dong-Dong Wu
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引用次数: 0

摘要

3-巯基丙酮酸硫转移酶(3-MST)广泛存在于不同的生物实体中,对硫化氢(H₂S)的产生至关重要。该酶在细胞质和线粒体中都起作用,3-MST介导3-巯基丙酮酸(3-MP)与二氢硫辛酸和硫氧还蛋白的反应产生硫化氢。除了3-MST外,还可以通过半胱硫氨酸β-合成酶(CBS)和半胱硫氨酸γ-裂解酶(CSE)的作用产生H₂S。氢气是一种具有治疗潜力的气体信号分子,对癌症、心血管疾病、神经系统疾病等多种疾病具有治疗和缓解作用。虽然CBS和CSE在癌症中的作用已经得到了广泛的研究和很好的描述,但关于3-MST在癌症中的功能和重要性的科学文献相对较少。本文重点介绍了3-MST在乳腺癌、肺癌、膀胱癌和结肠癌中的作用,强调了其作为治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of 3-mercaptopyruvate sulfurtransferase in cancer.

The enzyme 3-Mercaptopyruvate sulfurtransferase (3-MST) is widely present across different biological entities and is essential for the production of hydrogen sulfide (H₂S). This enzyme functions both in the cytosol and mitochondria, and 3-MST mediates the reaction of 3-Mercaptopyruvate (3-MP) with dihydrolipoic acid and thioredoxin to produce hydrogen sulfide. In addition to 3-MST, H₂S can also be produced through the actions of cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). H₂S, a gaseous signaling molecule with therapeutic potential, has been found to have therapeutic and alleviating effects on various diseases, including cancer, cardiovascular disease, and neurological disorders. While the roles of CBS and CSE in cancer have been extensively studied and well-described, relatively little information is available in the scientific literature regarding the function and importance of 3-MST in cancer. This article focuses on the role of 3-MST in breast cancer, lung cancer, bladder cancer, and colon cancer, emphasizing its potential as a therapeutic target.

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来源期刊
Cellular signalling
Cellular signalling 生物-细胞生物学
CiteScore
8.40
自引率
0.00%
发文量
250
审稿时长
27 days
期刊介绍: Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.
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