肠干细胞再生中hippo和Wnt通路的串扰。

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-07-24 DOI:10.1016/j.cellsig.2025.112023

Yanqiu Li, Yujun Hou, Yue He, Kexin Cheng, Ying Chen, Ying Li, Siyuan Zhou

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引用次数: 0

摘要

肠道干细胞（ISC）再生是维持肠道内环境平衡的关键。ISC的增殖和分化受干细胞生态位中特定细胞的调控，这些细胞主要通过分泌多种通路的相关配体来调节ISC的活性，其中Wnt通路是调节ISC再生的主要通路，Hippo通路在控制器官大小和修复损伤中发挥重要作用。越来越多的证据表明，这两种途径密切合作，共同调节ISCs的自我更新和再生，对维持肠道稳态和治疗肠道疾病具有重要意义。因此，我们概述了Wnt和Hippo通路在ISC再生和肠道疾病中的相互作用，这不仅揭示了维持肠道稳态的机制，而且为肠道疾病的新治疗策略铺平了道路。

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Crosstalk between hippo and Wnt pathways in intestinal stem cells regeneration

Intestinal stem cell (ISC) regeneration is the key to maintaining intestinal homeostasis. The proliferation and differentiation of ISCs are regulated by the specific cells in the stem cell niche, and these cells mainly regulate ISC activity through secreting related ligands of various pathways, among which the Wnt pathway is the primary pathway regulating ISC regeneration, and the Hippo pathway plays an important role in controlling organ size and repairing injury. Accumulating evidence has identified that these two pathways closely cooperate to regulate the self-renewal and regeneration of ISCs, which has important significance in the maintenance of intestinal homeostasis and the treatment of intestinal disorders. Therefore, we provide an overview of the interaction of the Wnt and Hippo pathways in ISC regeneration and intestinal diseases, which not only sheds light on the mechanisms of maintaining intestinal homeostasis but also paves the way for novel therapeutic strategies for intestinal diseases.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.