Venkat Sanjay Manubolu, April Kinninger, Suvasini Lakshmanan, Suraj Dahal, Keishi Ichikawa, Dhiran Verghese, Luay Alalawi, Jairo Aldana, Shriraj Susarla, Hoon J Seok, Chris Dailing, Sion K Roy, Anand Rohatgi, James P Earls, Matthew J Budoff
{"title":"冠状动脉斑块负担和特征的种族差异：南亚人和非西班牙裔白人的匹配CCTA队列研究。","authors":"Venkat Sanjay Manubolu, April Kinninger, Suvasini Lakshmanan, Suraj Dahal, Keishi Ichikawa, Dhiran Verghese, Luay Alalawi, Jairo Aldana, Shriraj Susarla, Hoon J Seok, Chris Dailing, Sion K Roy, Anand Rohatgi, James P Earls, Matthew J Budoff","doi":"10.1016/j.atherosclerosis.2025.120455","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>South Asians (SA) experience a significantly higher incidence of atherosclerotic cardiovascular disease (CVD) events compared to non-Hispanic whites (NHW). However, detailed plaque characteristics in SA, particularly assessed through quantitative coronary plaque analysis using coronary computed tomography angiography (CCTA), remain under-investigated. This study aimed to compare the characteristics of coronary plaque burden between SA and NHW using CCTA.</p><p><strong>Methods: </strong>In this cross-sectional study, we identified 165 SA subjects at our institution who underwent CCTA and matched them 1:1 for age, sex, BMI and diabetes mellitus with NHW. Quantitative coronary plaque analysis was reported by plaque subtypes in percent atheroma volume (PAV) and absolute plaque volumes. Kruskall-Wallis test was used to analyze the plaque volumes and PAV between the matched cohorts.</p><p><strong>Results: </strong>A total of 330 subjects (mean age: 65 ± 9.9 years; 74 % male; 32 % with diabetes) formed the study population. SA had higher total plaque PAV (median [IQR]: 11.9 [4.4, 22.0] vs. 6.2 [2.4, 14.2]), NCP PAV (5.1 [3.2, 8.1] vs. 3.8 [1.8, 6.5]), and calcified plaque PAV (4.9 [1.4, 12.7] vs. 2.4 [0.3, 7.5]) than NHW (p < 0.0001). Differences were significant for those under 55 and 65 years but not in those ≥65, except for calcified plaque PAV when stratified by age.</p><p><strong>Conclusion: </strong>Younger SA (<55 years) exhibited higher total, non-calcified, and calcified plaque burden compared to NHW, suggesting earlier CAD risk. CCTA may aid early detection and support aggressive prevention strategies in this high-risk population.</p>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":" ","pages":"120455"},"PeriodicalIF":5.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ethnic differences in coronary plaque burden and characteristics: A matched CCTA cohort study of South Asians and non-Hispanic Whites.\",\"authors\":\"Venkat Sanjay Manubolu, April Kinninger, Suvasini Lakshmanan, Suraj Dahal, Keishi Ichikawa, Dhiran Verghese, Luay Alalawi, Jairo Aldana, Shriraj Susarla, Hoon J Seok, Chris Dailing, Sion K Roy, Anand Rohatgi, James P Earls, Matthew J Budoff\",\"doi\":\"10.1016/j.atherosclerosis.2025.120455\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aims: </strong>South Asians (SA) experience a significantly higher incidence of atherosclerotic cardiovascular disease (CVD) events compared to non-Hispanic whites (NHW). However, detailed plaque characteristics in SA, particularly assessed through quantitative coronary plaque analysis using coronary computed tomography angiography (CCTA), remain under-investigated. This study aimed to compare the characteristics of coronary plaque burden between SA and NHW using CCTA.</p><p><strong>Methods: </strong>In this cross-sectional study, we identified 165 SA subjects at our institution who underwent CCTA and matched them 1:1 for age, sex, BMI and diabetes mellitus with NHW. Quantitative coronary plaque analysis was reported by plaque subtypes in percent atheroma volume (PAV) and absolute plaque volumes. Kruskall-Wallis test was used to analyze the plaque volumes and PAV between the matched cohorts.</p><p><strong>Results: </strong>A total of 330 subjects (mean age: 65 ± 9.9 years; 74 % male; 32 % with diabetes) formed the study population. SA had higher total plaque PAV (median [IQR]: 11.9 [4.4, 22.0] vs. 6.2 [2.4, 14.2]), NCP PAV (5.1 [3.2, 8.1] vs. 3.8 [1.8, 6.5]), and calcified plaque PAV (4.9 [1.4, 12.7] vs. 2.4 [0.3, 7.5]) than NHW (p < 0.0001). Differences were significant for those under 55 and 65 years but not in those ≥65, except for calcified plaque PAV when stratified by age.</p><p><strong>Conclusion: </strong>Younger SA (<55 years) exhibited higher total, non-calcified, and calcified plaque burden compared to NHW, suggesting earlier CAD risk. CCTA may aid early detection and support aggressive prevention strategies in this high-risk population.</p>\",\"PeriodicalId\":8623,\"journal\":{\"name\":\"Atherosclerosis\",\"volume\":\" \",\"pages\":\"120455\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Atherosclerosis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.atherosclerosis.2025.120455\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atherosclerosis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.atherosclerosis.2025.120455","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/19 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Ethnic differences in coronary plaque burden and characteristics: A matched CCTA cohort study of South Asians and non-Hispanic Whites.
Background/aims: South Asians (SA) experience a significantly higher incidence of atherosclerotic cardiovascular disease (CVD) events compared to non-Hispanic whites (NHW). However, detailed plaque characteristics in SA, particularly assessed through quantitative coronary plaque analysis using coronary computed tomography angiography (CCTA), remain under-investigated. This study aimed to compare the characteristics of coronary plaque burden between SA and NHW using CCTA.
Methods: In this cross-sectional study, we identified 165 SA subjects at our institution who underwent CCTA and matched them 1:1 for age, sex, BMI and diabetes mellitus with NHW. Quantitative coronary plaque analysis was reported by plaque subtypes in percent atheroma volume (PAV) and absolute plaque volumes. Kruskall-Wallis test was used to analyze the plaque volumes and PAV between the matched cohorts.
Results: A total of 330 subjects (mean age: 65 ± 9.9 years; 74 % male; 32 % with diabetes) formed the study population. SA had higher total plaque PAV (median [IQR]: 11.9 [4.4, 22.0] vs. 6.2 [2.4, 14.2]), NCP PAV (5.1 [3.2, 8.1] vs. 3.8 [1.8, 6.5]), and calcified plaque PAV (4.9 [1.4, 12.7] vs. 2.4 [0.3, 7.5]) than NHW (p < 0.0001). Differences were significant for those under 55 and 65 years but not in those ≥65, except for calcified plaque PAV when stratified by age.
Conclusion: Younger SA (<55 years) exhibited higher total, non-calcified, and calcified plaque burden compared to NHW, suggesting earlier CAD risk. CCTA may aid early detection and support aggressive prevention strategies in this high-risk population.
期刊介绍：
Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.
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