Correlation between multiple embryo transfers and the incidence of preterm birth and low birth weight: a network meta-analysis

Purpose

In vitro fertilization and embryo transfer (IVF-ET) has become crucial for infertile couples. Previous studies have suggested that multiple ETs are associated with increased risks of preterm birth and low birth weight. The current study aims to investigate this association.

Methods

PubMed, Cochrane Library, EMBASE, ScienceDirect, and China National Knowledge Infrastructure databases were systematically searched. Network meta-analysis was performed to compare the associations between different numbers of embryo transfers (≥ 2) and the incidence rates of preterm birth and low birth weight. Consistency and inconsistency models were applied to ensure reliability. Frequentist statistical methods used data integration. The surface under the cumulative ranking curve (SUCRA) value was used to rank the risks of preterm birth and low birth weight associated with varying numbers of ETs.

Results

There was a significant difference in the incidence of low birth weight between the 2-ET and 4-ET groups. The 4-ET group had the highest risks for preterm birth and low birth weight.

Conclusion

Multiple ETs are associated with increased risks of preterm birth and low birth weight. This study highlights the need for tailored clinical strategies to optimize pregnancy outcomes and mitigate complications.