lncRNA MEG3在肾脏疾病中的多重作用：关注机制、治疗和诊断潜力

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-07-24 DOI:10.1016/j.drudis.2025.104437

Bhupendra Puri , Syamantak Majumder , Anil Bhanudas Gaikwad

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引用次数: 0

摘要

肾脏疾病是一项全球性的健康挑战，影响到数百万人，并导致严重的发病率和死亡率。长链非编码rna有可能成为细胞过程中的调节因子，并参与肾脏疾病的病理生理改变。其中，MEG3因其在纤维化、细胞凋亡和炎症中的多种调控作用而受到关注。MEG3失调与慢性肾病、急性肾损伤、糖尿病肾病和肾细胞癌等疾病有关。然而，它参与内质网应激和自噬，以及肾脏疾病中的串扰，却知之甚少。因此，本文旨在强调MEG3在肾脏疾病的治疗和诊断中的作用及其在内质网应激和自噬中的调节机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The multifaceted role of lncRNA MEG3 in kidney disease: A focus on mechanisms, therapeutic and diagnostic potential

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The multifaceted role of lncRNA MEG3 in kidney disease: A focus on mechanisms, therapeutic and diagnostic potential

Kidney disease represents a global health challenge, affecting millions of people and contributing to significant morbidity and mortality. Long noncoding RNAs are potentially emerging as regulators in cellular processes and are involved in pathophysiological alterations in kidney disease. Among these, MEG3 has gained attention for its diverse regulatory roles in fibrosis, apoptosis and inflammation. MEG3 dysregulation has been implicated in conditions like chronic kidney disease, acute kidney injury, diabetic kidney disease and renal cell carcinoma. However, its involvement in endoplasmic reticulum (ER) stress and autophagy, crosstalk in kidney disease, is poorly understood. Hence, this review aims to highlight the role of MEG3 as a therapeutic and diagnostic viewpoint in kidney disease and its regulatory mechanism in ER stress and autophagy.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.