Atomically Precise Octanuclear Cu(II) Complex With [Ph2PO2]− for Chemodynamic Therapy

In recent research, an atomically precise Cu(II) complex (Cu8) consisting of eight copper atoms has been successfully synthesized. This complex exhibits a unique capability to catalyze a Fenton-like reaction within the tumor microenvironment (TME), which is characterized by overexpressed hydrogen peroxide. The Cu(II) complex Cu8 exploits this condition to generate highly cytotoxic hydroxyl radicals. These radicals are extremely effective in inducing programmed cell death or apoptosis in HeLa cells, a type of cervical cancer cell, and additionally cause significant damage to the mitochondria (the powerhouses of the cell). Due to these properties, the complex functions as a potent chemodynamic therapy (CDT) agent, demonstrating promising antitumor potential. The precise coordination of the [Ph₂PO₂]⁻ ligand within the complex is critical to its effectiveness in catalyzing the Fenton-like reaction, thereby enabling its therapeutic application in chemodynamic therapy.