{"title":"广泛性焦虑障碍患者在Go/No-Go任务中的前额叶皮层活性低下","authors":"Chien-An Chen, Po-Tsen Lin, Meng-Yu Hsu, Cheng-Yang Lee, I-Ming Chen, Yi-Ting Lin, Yu-Jui Huang, Pao-Huan Chen, Jia-Jin Chen, Gong-Hong Lin, Yi-Jing Huang","doi":"10.1155/da/9040115","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Background and Objective:</b> Generalized anxiety disorder (GAD) is a prevalent mental health condition affecting cognitive functions like response inhibition. The neural mechanisms underlying the interplay between inhibitory ability and anxiety regulation in GAD remain unclear. This study aimed to investigate the prefrontal cortex (PFC) alterations when anxiety regulation shares neural resources with response inhibition in patients with GAD compared to healthy controls and to explore the relationship between anxiety and PFC activity.</p>\n <p><b>Methods:</b> The hemodynamic responses of bihemispheric PFC were measured in 19 GAD patients and 38 healthy controls using functional near-infrared spectroscopy (fNIRS) during the Go/No-Go task and were compared between the groups. The correlations between PFC activity and task performance and those between PFC activity and anxiety levels were analyzed.</p>\n <p><b>Results:</b> The GAD group exhibited lower hemoglobin concentration across the PFC during both baseline and task sessions, with significant hypoactivity in the bihemispheric dorsomedial PFC (DMPFC) at baseline (<i>p</i> = 0.035–0.049), and more widespread hypoactivity during the task in the bihemispheric DMPFC (<i>p</i> < 0.001–0.033) and dorsolateral PFC (DLPFC; <i>p</i> = 0.012–0.042), as well as the right ventromedial PFC (VMPFC; <i>p</i> = 0.019–0.037). Higher baseline prefrontal activity was associated with poorer task accuracy (<i>r</i> = −0.576 to −0.417) and greater trait anxiety (<i>r</i> = 0.441–0.514). When transitioning to the task, better accuracy correlated with increased activation in the left DMPFC (<i>r</i> = 0.405–0.593), whereas higher anxiety levels were linked to reduced activation in the left DMPFC (<i>r</i> = −0.512) and right DMPFC (<i>r</i> = −0.435).</p>\n <p><b>Conclusion:</b> This study reveals that patients with GAD exhibit significant hypoactivity in the PFC during response inhibition, correlating with both task performance and anxiety levels. These findings emphasize the importance of targeting PFC dysfunction in the development of diagnostic tools and therapeutic interventions for GAD.</p>\n </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2025 1","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9040115","citationCount":"0","resultStr":"{\"title\":\"Hypoactivity of the Prefrontal Cortex During Go/No-Go Task in Patients With Generalized Anxiety Disorder\",\"authors\":\"Chien-An Chen, Po-Tsen Lin, Meng-Yu Hsu, Cheng-Yang Lee, I-Ming Chen, Yi-Ting Lin, Yu-Jui Huang, Pao-Huan Chen, Jia-Jin Chen, Gong-Hong Lin, Yi-Jing Huang\",\"doi\":\"10.1155/da/9040115\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><b>Background and Objective:</b> Generalized anxiety disorder (GAD) is a prevalent mental health condition affecting cognitive functions like response inhibition. The neural mechanisms underlying the interplay between inhibitory ability and anxiety regulation in GAD remain unclear. This study aimed to investigate the prefrontal cortex (PFC) alterations when anxiety regulation shares neural resources with response inhibition in patients with GAD compared to healthy controls and to explore the relationship between anxiety and PFC activity.</p>\\n <p><b>Methods:</b> The hemodynamic responses of bihemispheric PFC were measured in 19 GAD patients and 38 healthy controls using functional near-infrared spectroscopy (fNIRS) during the Go/No-Go task and were compared between the groups. The correlations between PFC activity and task performance and those between PFC activity and anxiety levels were analyzed.</p>\\n <p><b>Results:</b> The GAD group exhibited lower hemoglobin concentration across the PFC during both baseline and task sessions, with significant hypoactivity in the bihemispheric dorsomedial PFC (DMPFC) at baseline (<i>p</i> = 0.035–0.049), and more widespread hypoactivity during the task in the bihemispheric DMPFC (<i>p</i> < 0.001–0.033) and dorsolateral PFC (DLPFC; <i>p</i> = 0.012–0.042), as well as the right ventromedial PFC (VMPFC; <i>p</i> = 0.019–0.037). Higher baseline prefrontal activity was associated with poorer task accuracy (<i>r</i> = −0.576 to −0.417) and greater trait anxiety (<i>r</i> = 0.441–0.514). When transitioning to the task, better accuracy correlated with increased activation in the left DMPFC (<i>r</i> = 0.405–0.593), whereas higher anxiety levels were linked to reduced activation in the left DMPFC (<i>r</i> = −0.512) and right DMPFC (<i>r</i> = −0.435).</p>\\n <p><b>Conclusion:</b> This study reveals that patients with GAD exhibit significant hypoactivity in the PFC during response inhibition, correlating with both task performance and anxiety levels. These findings emphasize the importance of targeting PFC dysfunction in the development of diagnostic tools and therapeutic interventions for GAD.</p>\\n </div>\",\"PeriodicalId\":55179,\"journal\":{\"name\":\"Depression and Anxiety\",\"volume\":\"2025 1\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/da/9040115\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Depression and Anxiety\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/da/9040115\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Depression and Anxiety","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/da/9040115","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Hypoactivity of the Prefrontal Cortex During Go/No-Go Task in Patients With Generalized Anxiety Disorder
Background and Objective: Generalized anxiety disorder (GAD) is a prevalent mental health condition affecting cognitive functions like response inhibition. The neural mechanisms underlying the interplay between inhibitory ability and anxiety regulation in GAD remain unclear. This study aimed to investigate the prefrontal cortex (PFC) alterations when anxiety regulation shares neural resources with response inhibition in patients with GAD compared to healthy controls and to explore the relationship between anxiety and PFC activity.
Methods: The hemodynamic responses of bihemispheric PFC were measured in 19 GAD patients and 38 healthy controls using functional near-infrared spectroscopy (fNIRS) during the Go/No-Go task and were compared between the groups. The correlations between PFC activity and task performance and those between PFC activity and anxiety levels were analyzed.
Results: The GAD group exhibited lower hemoglobin concentration across the PFC during both baseline and task sessions, with significant hypoactivity in the bihemispheric dorsomedial PFC (DMPFC) at baseline (p = 0.035–0.049), and more widespread hypoactivity during the task in the bihemispheric DMPFC (p < 0.001–0.033) and dorsolateral PFC (DLPFC; p = 0.012–0.042), as well as the right ventromedial PFC (VMPFC; p = 0.019–0.037). Higher baseline prefrontal activity was associated with poorer task accuracy (r = −0.576 to −0.417) and greater trait anxiety (r = 0.441–0.514). When transitioning to the task, better accuracy correlated with increased activation in the left DMPFC (r = 0.405–0.593), whereas higher anxiety levels were linked to reduced activation in the left DMPFC (r = −0.512) and right DMPFC (r = −0.435).
Conclusion: This study reveals that patients with GAD exhibit significant hypoactivity in the PFC during response inhibition, correlating with both task performance and anxiety levels. These findings emphasize the importance of targeting PFC dysfunction in the development of diagnostic tools and therapeutic interventions for GAD.
期刊介绍：
Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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