可见光促进了胺、α -酮酸和单质硫的Willgerodt-Kindler型硫胺化反应

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-07-28 DOI:10.1002/ejoc.202500708

Jigang Gao, Taimin Wang, Peng Li, Yun Luo, Lijing Fang, Hongbin Zhai, Jinlin Wang, Bin Cheng

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引用次数: 0

摘要

在温和条件下，建立了一种可见光促进的Willgerodt-Kindler型胺、α -酮酸和单质硫的硫胺化反应。广泛研究了各种现成的原料，包括伯胺/仲胺、芳基/烷基胺、铵盐、含氨基药物和氨基酸酯，提供了27种在无金属和无氧化剂条件下中高产量的硫酰胺的例子。

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Visible‐Light‐Promoted Willgerodt–Kindler‐Type Thioamidation Reaction of Amines, α‐Ketoacids, and Elemental Sulfur

A visible‐light‐promoted Willgerodt–Kindler‐type thioamidation reaction of amines, α‐ketoacids, and elemental sulfur under mild conditions has been developed. A wide variety of readily available feedstocks are extensively investigated, including primary/secondary amines, aryl/alkyl amines, ammonium salts, amino‐containing pharmaceuticals, and amino acid esters, providing 27 examples of thioamides in moderate to high yields under metal‐free and oxidant‐free conditions.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.