Palladium‐Catalyzed Cross‐Electrophile Coupling: A Strategy for CC Bond Formation between Two Electrophiles

Palladium‐catalyzed cross‐electrophile coupling (XEC) has emerged as a powerful strategy for selectively forming carbon–carbon and carbon–heteroatom bonds from two distinct electrophiles. This approach eliminates the need for preformed organometallic reagents by utilizing in situ reduction to generate reactive intermediates under mild conditions while enhancing functional group tolerance. This review provides a comprehensive overview of recent advances in palladium‐catalyzed XEC transformations, highlighting novel strategies, mechanistic insights, ligand and catalyst design, substrate scope, and synthetic applications. Additionally, current challenges and future directions in this fast‐progressing field, aiming to inspire further innovation in sustainable catalysis are discussed.