可见光下C(sp3) _ (O)键的光催化羧酸脱羧

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-07-28 DOI:10.1002/ejoc.202500579

Zhiyang Ma, Liang Zhang, Jinglan Wen, Yahao Huang, Peng Hu

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引用次数: 0

摘要

C（sp3）键的便捷构造在有机合成中具有重要意义。本文报道了一种可见光驱动铁催化的烷基羧酸脱羧反应，通过TEMPO捕获生成的烷基自由基，使C(sp3) - _ (O)键形成。该方法具有成本低、基板兼容性广、操作简单等特点。它不仅为C(sp3) - O键的构建提供了有效的方法，而且还通过对TEMPO衍生物的后续修饰展示了在合成化学中的潜在应用。

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Photocatalytic Decarboxylation of Carboxylic Acids by Iron Catalysis for the Construction of C(sp3)O Bonds under Visible Light

The facile construction of C(sp3)O bonds holds significant importance in organic synthesis. Herein, a visible‐light‐driven iron‐catalyzed decarboxylation of alkyl carboxylic acids is reported, enabling C(sp3)O bond formation through the trapping of generated alkyl radicals with TEMPO. This method is characterized by its low cost, broad substrate compatibility, and operational simplicity. Not only does it provides an efficient approach to C(sp3)O bond construction, but also it demonstrates potential applications in synthetic chemistry through subsequent modifications of TEMPO derivatives.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.