YAP-TAZ过度激活促进肾小球上皮增生性疾病

IF 39.8 1区 医学 Q1 UROLOGY & NEPHROLOGY
Monica Wang
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引用次数: 0

摘要

在塌陷性肾小球病或月牙状肾小球肾炎等疾病中,上皮细胞增殖是肾小球损伤的关键驱动因素。两项新研究,一项由Darren Yuen领导,另一项由Pierre Isnard和Fabiola Terzi领导,强调了YAP (es相关蛋白)和TAZ(具有pdz结合基序的转录辅激活因子)过度激活在肾小球增生性表型中的作用。Yuen及其同事将免疫染色和空间转录组学应用于塌陷性肾小球病(CG)或抗中性粒细胞细胞质抗体血管炎(ANCA)诱导的新月形肾小球肾炎(cGN)患者的肾活检组织。他们发现,与健康组织相比,在这两种情况下,YAP和TAZ的核富集,以及YAP - TAZ诱导基因的表达增加,表明这些转录辅助因子在肾小球增生性疾病中的激活增强。在小鼠足细胞中,YAP-TAZ抑制剂LATS(大肿瘤抑制激酶)1和2的特异性缺失导致结构异常和细胞外基质基因的表达增加。在体内,与野生型对照相比,lats缺陷小鼠在系膜细胞和壁上皮细胞(PECs)中增殖和促纤维化基因表达增强。在这些小鼠中,缺失Yap或Taz部分地恢复了CG表型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

YAP–TAZ overactivation promotes glomerular epithelial proliferative disease

YAP–TAZ overactivation promotes glomerular epithelial proliferative disease
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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