{"title":"IUBMB 2023年氨基酰基trna合成酶重点会议","authors":"Patrick O'Donoghue, Ilka U. Heinemann","doi":"10.1002/iub.70041","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>By ligating amino acids to their cognate transfer RNAs (tRNAs), the aminoacyl-tRNA synthetases (AARSs) establish the genetic code in all living cells. This special issue of <i>IUBMB Life</i> is dedicated to the IUBMB Focused Meeting on AARSs in 2023 and includes 12 original research articles and reviews that demonstrate some of the significant advances in AARS biology that were featured at the meeting. The articles focus on the role of AARS variants in human disease, molecular evolution of AARSs, synthetic biology applications involving AARSs, and the roles of AARSs and tRNAs in regulating protein synthesis. Together these studies reveal an expanded understanding of the function of AARSs in diverse cells and organisms and the application of these discoveries to biotechnology and medicine.</p>\n </div>","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":"77 7","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases 2023\",\"authors\":\"Patrick O'Donoghue, Ilka U. Heinemann\",\"doi\":\"10.1002/iub.70041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>By ligating amino acids to their cognate transfer RNAs (tRNAs), the aminoacyl-tRNA synthetases (AARSs) establish the genetic code in all living cells. This special issue of <i>IUBMB Life</i> is dedicated to the IUBMB Focused Meeting on AARSs in 2023 and includes 12 original research articles and reviews that demonstrate some of the significant advances in AARS biology that were featured at the meeting. The articles focus on the role of AARS variants in human disease, molecular evolution of AARSs, synthetic biology applications involving AARSs, and the roles of AARSs and tRNAs in regulating protein synthesis. Together these studies reveal an expanded understanding of the function of AARSs in diverse cells and organisms and the application of these discoveries to biotechnology and medicine.</p>\\n </div>\",\"PeriodicalId\":14728,\"journal\":{\"name\":\"IUBMB Life\",\"volume\":\"77 7\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IUBMB Life\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iub.70041\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUBMB Life","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iub.70041","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
The IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases 2023
By ligating amino acids to their cognate transfer RNAs (tRNAs), the aminoacyl-tRNA synthetases (AARSs) establish the genetic code in all living cells. This special issue of IUBMB Life is dedicated to the IUBMB Focused Meeting on AARSs in 2023 and includes 12 original research articles and reviews that demonstrate some of the significant advances in AARS biology that were featured at the meeting. The articles focus on the role of AARS variants in human disease, molecular evolution of AARSs, synthetic biology applications involving AARSs, and the roles of AARSs and tRNAs in regulating protein synthesis. Together these studies reveal an expanded understanding of the function of AARSs in diverse cells and organisms and the application of these discoveries to biotechnology and medicine.
期刊介绍：
IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
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