一种基于NIR-II AIE发光剂的纳米平台，具有一氧化氮控释特性，用于NIR-II荧光引导的光动力/光热/气体联合治疗

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-07-22 DOI:10.1016/j.dyepig.2025.113060

Siyu Zhang , Weiping Zhou , Wei Zhou , Ruohui Zhang , Shuang Song , Chang Liu , Ying Li , Di He , Mahmood Hassan Akhtar , Cong Yu

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引用次数: 0

摘要

光疗结合了光热疗法和光动力疗法，为癌症的治疗提供了一种有吸引力的策略。然而，提高其治疗效果仍然是一个重大挑战。一氧化氮（NO）可以作为一种有价值的辅助手段来克服光疗的局限性，荧光成像可以实时、在体内跟踪治疗剂，优化治疗窗口并改善结果。本文报道了用两亲性聚合物F127包封小分子聚集诱导发射（AIE）光敏剂（TDPB）和热敏性一氧化氮（NO）供体（BNN6）制备的多功能纳米材料平台（TBN）的设计和合成。TBN通过联合PDT、PTT和NO治疗，使NIR-II荧光成像（FLI）引导的多模式癌症治疗成为可能。具体来说，TDPB具有多种功能，包括NIR-II FLI，有效的羟基自由基（•OH）生成和高光热转换效率（PCE）性能。NIR-II成像有助于在光疗过程中精确定位肿瘤。此外，TDPB的光热效应触发BNN6的热响应性NO释放，通过气体疗法增强治疗效果。因此，体外和体内实验都清楚地表明，TBN可以实现精确的肿瘤靶向和有效的消融，同时保持良好的生物相容性。因此，本研究提出了一种设计多功能治疗纳米平台的新策略，提高了治疗精度和疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A NIR-II AIE luminogen based nanoplatform with nitric oxide controlled release properties for NIR-II fluorescence guided combined photodynamic/photothermal/gas therapy

查看原文本刊更多论文

A NIR-II AIE luminogen based nanoplatform with nitric oxide controlled release properties for NIR-II fluorescence guided combined photodynamic/photothermal/gas therapy

Phototherapy, which integrates photothermal therapy (PTT) and photodynamic therapy (PDT), offers an appealing strategy for the treatment of cancer. However, enhancing its therapeutic efficacy remains a significant challenge. Nitric oxide (NO) can serve as a valuable adjunct to overcome the limitations of phototherapy, and fluorescence imaging enables real-time, in vivo tracking of therapeutic agents, optimizing the treatment window and improving outcomes. Herein, we report the design and synthesis of a multifunctional nanomaterial platform (TBN) fabricated by encapsulating a small-molecule aggregation-induced emission (AIE) photosensitizer (TDPB) and a thermoresponsive nitric oxide (NO) donor (BNN6) using the amphiphilic polymer F127. TBN enables NIR-II fluorescence imaging (FLI)-guided multimodal cancer therapy by combining PDT, PTT, and NO therapy. Specifically, TDPB is capable of multiple functions including NIR-II FLI, effective hydroxyl radical (•OH) production and high photothermal conversion efficiency (PCE) performance. NIR-II imaging facilitates precise localization of the tumor during the phototherapeutic process. Additionally, the photothermal effect of TDPB triggers heat-responsive NO release from BNN6, enhancing therapeutic efficacy through gas therapy. Consequently, both in vitro and in vivo experiments have clearly demonstrated that TBN can achieve precise tumor targeting and effective ablation while maintaining excellent biocompatibility. This study thus presents a novel strategy for designing a multifunctional therapeutic nanoplatform with enhanced treatment precision and efficacy.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.