侵袭性小叶癌1例，强调18f -氟雌二醇PET的新作用

Q4 Medicine

Radiology Case Reports Pub Date : 2025-07-28 DOI:10.1016/j.radcr.2025.06.105

Michael Wallace MMS, MS , Anahita Tavana MD , Amie Leon DO , Santo Maimone MD , Haley Letter MD

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引用次数: 0

摘要

浸润性小叶癌（ILC）提出了重大的诊断挑战，由于其微妙的表现在乳房x光检查。其低代谢活性进一步限制了氟-18 (18F)-氟脱氧葡萄糖-正电子发射断层扫描（FDG-PET）对转移性病变的检测。相比之下，靶向功能性雌激素受体（ER）表达的18F-fluoroestradiol-PET （FES-PET）可增强ER阳性转移灶的可视化。我们报告一例转移性右乳ILC，在最初的乳房x光检查和超声检查中只有细微的可疑发现。作为转移性检查的一部分，FES-PET/MRI被利用，并确定了在初始FDG-PET/CT上没有代谢活性的其他转移性病灶。本病例强调了乳腺成像中ILC检测的挑战，并强调了FES-PET在其管理中的新兴作用。

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A case of invasive lobular carcinoma, highlighting the emerging role of 18F-Fluoroestradiol PET

Invasive lobular carcinoma (ILC) presents significant diagnostic challenges due to its subtle presentation on mammography. Its low metabolic activity further limits the detection of metastatic lesions using fluorine-18 (¹⁸F)-fluorodeoxyglucose-positron emission tomography (FDG-PET). In contrast, ¹⁸F-fluoroestradiol-PET (FES-PET), which targets functional estrogen receptor (ER) expression, enhances visualization of ER-positive metastases. We present a case of metastatic right breast ILC with only subtle suspicious findings on initial mammography and ultrasound. As part of the metastatic workup, FES-PET/MRI was utilized and identified additional metastatic lesions that were not metabolically active on the initial FDG-PET/CT. This case underscores the challenges of ILC detection in breast imaging and highlights the emerging role of FES-PET in its management.

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来源期刊

Radiology Case Reports Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

1.10

自引率

0.00%

发文量

1074

审稿时长

30 days

期刊介绍： The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.