甲状腺功能减退患者血清同型半胱氨酸与肾功能的关系：伊朗东北部的一项病例对照研究

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-07-26 DOI:10.1016/j.bbrep.2025.102176

Tamara Nagem Faisal , Mahin Gholipour , Somayyeh Sadani , Jahanbakhsh Asadi

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引用次数: 0

摘要

背景/目的甲状腺功能减退患者血清同型半胱氨酸（Hcy）与肾功能的关系尚不完全清楚。本病例对照研究探讨了诊断为临床甲状腺功能减退症（CH）的患者高同型半胱氨酸血症（HHcy）与肾功能检查的关系。方法从伊朗东北部一家转诊诊所招募45例CH病例和45例匹配对照。采用ELISA技术检测血清Hcy，并估算Spearman相关系数以评估Hcy与各项肾功能参数之间的相关性。结果甲状腺功能正常患者Hcy水平（22.63±1.21 vs 12.96±0.24 μmol/L, p = 0.001）显著高于甲状腺功能正常患者。在CH患者中，82.2%患有HHcy（60%为轻度，12.2%为中度），而对照组中只有13.3%患有轻度HHcy。Hcy水平与TSH呈正相关(r = 0.528；p = 0.001), eGFR (r = - 0.418；P = 0.004)，尿素(r = 0.371；P = 0.012)，肌酐(r = 0.384；p = 0.009)。多因素logistic回归显示Hcy和CH之间存在显著相关性[OR = 2.01, 95% CI: 1.48-2.72, p = 0.001]，即使在调整肾脏参数后也是如此。结论血清Hcy随进行性甲状腺功能不全而升高，与肾功能变化无关，可能是冠心病发生的潜在危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Association between serum homocysteine and kidney function in hypothyroid patients: A case-control study in Northeast Iran

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Association between serum homocysteine and kidney function in hypothyroid patients: A case-control study in Northeast Iran

Background/objectives

The relationship between serum homocysteine (Hcy) and kidney function in hypothyroidism is not fully understood. This case-control study investigated the association of hyperhomocysteinemia (HHcy) with kidney function tests in patients diagnosed with clinical hypothyroidism (CH).

Methods

Forty-five CH cases and 45 matched controls were recruited from a referral clinic in northeast Iran. Serum Hcy was measured using ELISA technology, and Spearman's correlation coefficients were estimated to assess the association between Hcy and various kidney function parameters.

Results

In CH patients, the average Hcy level was significantly higher than in those with normal thyroid function (22.63 ± 1.21 vs 12.96 ± 0.24 μmol/L, p = 0.001). Among CH patients, 82.2 % had HHcy (60 % mild, 12.2 % moderate), while only 13.3 % of controls had mild HHcy. Hcy levels were positively correlated with TSH (r = 0.528; p = 0.001), eGFR (r = - 0.418; p = 0.004), urea (r = 0.371; p = 0.012), and creatinine (r = 0.384; p = 0.009) in CH patients. Multivariate logistic regression revealed a significant relationship between Hcy and CH [OR = 2.01, 95 % CI: 1.48–2.72, p = 0.001], even after adjusting for kidney parameters.

Conclusions

Serum Hcy was increased with progressive thyroid insufficiency, independent of changes in kidney function, and could be considered a potential risk factor for developing coronary heart disease.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.