透明质酸修饰Fe3O4对银屑病样皮肤增生的磁靶向光热抑制作用

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-07-24 DOI:10.1016/j.colsurfb.2025.114985

Qian Chang , Kaihao Ma , Guanyu Tan , Jianzhi Mao , Qiwei Tian , Yuanjie Zhu , Shiping Yang , Lu An

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引用次数: 0

摘要

光热疗法（PTT）有望成为银屑病的一种新兴治疗方法；然而，其效果可能受到目标部位光热剂浓度不足的限制。在此，我们设计了一种磁靶向增强策略，通过透明质酸-氧化铁（Fe3O4@HA）纳米复合材料缓解银屑病状角质细胞增殖。合成的Fe3O4@HA具有强铁磁性和近红外吸收，使其具有磁靶向能力，可以选择性地在磁控制区域积累，用于特定位点的PTT。在磁场区域内显著增加高达10 °C，突出了Fe3O4@HA的特殊磁定向和光热特性。银屑病治疗小鼠模型进一步证实了磁靶向作用下Fe3O4@HA在病变部位的高效蓄积，特异位点近红外光照射引起的高温可诱导细胞凋亡，从而强调了Fe3O4@HA治疗银屑病的潜在疗效。该策略为缓解银屑病相关症状提供了一个有希望的方法。

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Hyaluronic acid-modified Fe3O4 for magnetic-targeted photothermal suppression of psoriasis-like skin hyperplasia

Photothermal therapy (PTT) shows promise as an emerging treatment for psoriasis; however, its efficacy may be limited by insufficient concentrations of photothermal agents at the targeted sites. Herein, we devised a magnetic targeting enhanced strategy for alleviate psoriasiform keratinocyte proliferation by hyaluronic acid-iron oxide (Fe₃O₄@HA) nanocomposites. The synthesized Fe₃O₄@HA exhibit strong ferromagnetism and near infrared absorption, allowing it to magnetic targeting capabilities to selectively accumulate in magnetic control regions for site-specific PTT. A significant increase of up to 10 °C within the magnetic field region, highlighting exceptional both magnetic-targeted and photothermal properties of Fe₃O₄@HA. The murine model for psoriasis treatment further confirms the efficient accumulation of Fe₃O₄@HA in the diseased area by magnetic targeting, and elevated temperatures induced by site-specific near-infrared light irradiation can induce cell apoptosis, thus underscoring the potential therapeutic efficacy of Fe₃O₄@HA for psoriasis. This strategy offers a promising approach for the relief of psoriasis-related symptoms.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.