常温机器灌注在肾移植中应用的机遇与挑战

IF 15.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Ton J. Rabelink, Sarah Hosgood, Thomas Minor, Markus Selzner, Annemarie Weissenbacher, Henri GD Leuvenink, Stefan Schneeberger
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引用次数: 0

摘要

终末期肾脏疾病和透析是限制生命和生活方式的条件,对卫生保健系统的巨大成本。尽管器官严重短缺,每年仍有成千上万的器官被回收用于移植,因为器官质量不足和/或器官保存时间有限。常温肾机灌注(NMP)有可能通过改善保存、延长保存时间、肾脏质量评估、修复和治疗来解决这一问题。在此,我们对这项技术的潜力和突破的障碍进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation

Opportunities and challenges with the implementation of normothermic machine perfusion in kidney transplantation

End stage kidney disease and dialysis are lifetime limiting and lifestyle-defining conditions with enormous costs to the health care system. Despite a severe organ shortage, thousands of organs that are retrieved for transplantation go to waste every year because of the presumed inadequacy of organ quality and/or the limited organ preservation time. Normothermic kidney machine perfusion (NMP) holds the potential to resolve this through improved preservation, prolonged preservation time, kidney quality assessment, reconditioning and treatment. We herein develop a perspective on the potential, but also the hurdles towards the breakthrough of this technology.

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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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