患有饮食失调或饮食失调的个体使用致幻剂:来自国际MED-FED调查的结果。

IF 4.5 3区 医学 Q2 NUTRITION & DIETETICS
Sarah-Catherine Rodan, Noah Meez, Sophie Lloyd-Hurwitz, Miguel A Bedoya-Pérez, Anastasia Suraev, Natasha Sommer, Kayla Greenstien, Sarah Maguire, Iain S McGregor
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引用次数: 0

摘要

背景:进食障碍(EDs)的有效治疗方法很少,迫切需要新的干预措施。饮食失调的药物和其他药物(MED-FED)调查调查了ed成人的生活经历,包括处方药和非处方药的使用。在这项调查中,迷幻药因其对ED症状和一般心理健康的影响而受到高度评价。在这里,我们提供了一个更细粒度的分析数据的子集有关迷幻药的使用从这个调查。方法:MED-FED调查招募了自我报告临床诊断为ED或饮食失调的成年人,这些成年人目前尚未确诊,但造成了显著的痛苦。研究了近期和终身致幻剂使用者相对于非使用者的人口统计数据,以及他们对其他处方药和非处方药的使用情况,以及合并症。定性分析用于检查关于使用致幻剂的开放式评论中出现的主题。结果:在完成调查的5247名参与者中,1699/5247(32.4%)报告终生使用迷幻药,其中1019/5247(19.4%)在过去12个月内使用过迷幻药。典型的使用包括不频繁的消费,每年一次或两次,裸盖菇素,LSD, 2-CB或DMT。那些报告最近使用迷幻药的人更年轻,目前使用处方药或最近因ED住院的可能性更小。他们更有可能使用其他非处方药(如大麻、氯胺酮、兴奋剂),并报告共病ADHD、PTSD、ASD和药物滥用。被诊断为神经性厌食症的参与者报告使用迷幻药的可能性较小,而未被诊断为ED的参与者更有可能使用迷幻药。对反应的定性分析(n = 200)揭示了深刻转变的主题,增加的连通性,以及对迷幻体验后疾病的新见解。少数受访者报告了微剂量的好处。一些受访者在他们的开放式评论中报告了不良后果,包括“糟糕的旅行”(n = 15)和使用迷幻药后ED症状恶化(n = 8)。结论:这些发现为ed患者使用迷幻药提供了独特的见解。这一结果与新出现的证据一致,表明致幻剂可能对这一人群有益,这突出了进一步研究的必要性,包括临床试验,以探索其有效性和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychedelic use in individuals living with eating disorders or disordered eating: findings from the international MED-FED survey.

Background: There are few effective treatments for eating disorders (EDs), and new interventions are urgently needed. The MEDication and other drugs For Eating Disorders ("MED-FED") survey investigated the lived experience of adults with EDs regarding their prescription and non-prescription drugs use. Psychedelic drugs were highly rated in this survey for their impact on ED symptoms and general mental health. Here, we provide a more granular analysis of a subset of the data pertaining to psychedelic drug use from this survey.

Methods: The MED-FED survey recruited adults who self-reported either a clinically diagnosed ED or disordered eating that was currently undiagnosed but causing significant distress. The demographics of recent and lifetime psychedelic users relative to non-users were examined, as well as their use of other prescription and non-prescription drugs, and co-morbid conditions. Qualitative analysis was used to examine themes emerging from open-ended comments around use of psychedelic drugs.

Results: Of the 5247 participants who completed the survey, 1699/5247 (32.4%) reported lifetime psychedelic use, with 1019/5247 (19.4%) having used in the last 12 months. Typical use involved infrequent consumption, once or twice per year, of psilocybin, LSD, 2-CB, or DMT. Those who reported recent psychedelic use were younger and less likely to currently use prescription drugs or to have been recently hospitalised for their ED. They were more likely to use other non-prescription drugs (e.g. cannabis, ketamine, stimulants) and to report co-morbid ADHD, PTSD, ASD, and substance misuse. Participants with a diagnosis of anorexia nervosa were less likely to report psychedelic use, while those with an undiagnosed ED were more likely. Qualitative analysis of responses (n = 200) revealed themes of profound transformation, increased connectedness, and new insights into illness following psychedelic experiences. A handful of respondents reported benefits from microdosing. A few respondents reported adverse outcomes in their open-ended comments, including "bad trips" (n = 15) and worsened ED symptoms (n = 8) after psychedelic use.

Conclusions: These findings provide a unique insight into psychedelic use among individuals with EDs. The results align with emerging evidence suggesting that psychedelics may be beneficial in this population, highlighting the need for further research, including clinical trials, to explore their efficacy and safety.

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来源期刊
Journal of Eating Disorders
Journal of Eating Disorders Neuroscience-Behavioral Neuroscience
CiteScore
5.30
自引率
17.10%
发文量
161
审稿时长
16 weeks
期刊介绍: Journal of Eating Disorders is the first open access, peer-reviewed journal publishing leading research in the science and clinical practice of eating disorders. It disseminates research that provides answers to the important issues and key challenges in the field of eating disorders and to facilitate translation of evidence into practice. The journal publishes research on all aspects of eating disorders namely their epidemiology, nature, determinants, neurobiology, prevention, treatment and outcomes. The scope includes, but is not limited to anorexia nervosa, bulimia nervosa, binge eating disorder and other eating disorders. Related areas such as important co-morbidities, obesity, body image, appetite, food and eating are also included. Articles about research methodology and assessment are welcomed where they advance the field of eating disorders.
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