Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini
{"title":"GDF15在饮食失调中升高，并通过胃饥饿素参与肠脑轴","authors":"Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini","doi":"10.1002/erv.70018","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored.</p><p><strong>Method: </strong>A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants from the general population). Ghrelin and GDF15 serum levels were measured with immunosorbent assay kits.</p><p><strong>Results: </strong>Ghrelin was elevated in patients with an eating disorder compared to healthy controls (age and BMI-adjusted ANCOVA, F-value 4.084, p-value 0.008). GDF15 was significantly correlated with ghrelin (Spearman rho 0.430, p-value < 0.001) and BMI (rho = -0.176, p-value = 0.025). GDF15 predicted the BMI of patients with anorexia nervosa and individuals from the general population, again being elevated at lower BMI (linear regression beta -0.254, p-value 0.005). The effect of GDF15 on BMI was observed as under the mediation of ghrelin (direct effect -0.056, p-value 0.577; indirect effect -0.199, p-value < 0.001).</p><p><strong>Conclusions: </strong>Present results provide novel insights into the role of GDF15 in eating disorders, describing its serum level in this clinical population for the first time. In addition, a positive correlation between GDF15 and ghrelin serum levels is also reported for the first time.</p>","PeriodicalId":48117,"journal":{"name":"European Eating Disorders Review","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut-Brain Axis via Ghrelin.\",\"authors\":\"Livio Tarchi, Giulia Brancolini, Sara Giachetti, Gaia Maiolini, Emanuele Cassioli, Eleonora Rossi, Gianluca Villa, Rachele Garella, Roberta Squecco, Paolo Rovero, Paolo Comeglio, Valdo Ricca, Francesco De Logu, Romina Nassini, Giovanni Castellini\",\"doi\":\"10.1002/erv.70018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored.</p><p><strong>Method: </strong>A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants from the general population). Ghrelin and GDF15 serum levels were measured with immunosorbent assay kits.</p><p><strong>Results: </strong>Ghrelin was elevated in patients with an eating disorder compared to healthy controls (age and BMI-adjusted ANCOVA, F-value 4.084, p-value 0.008). GDF15 was significantly correlated with ghrelin (Spearman rho 0.430, p-value < 0.001) and BMI (rho = -0.176, p-value = 0.025). GDF15 predicted the BMI of patients with anorexia nervosa and individuals from the general population, again being elevated at lower BMI (linear regression beta -0.254, p-value 0.005). The effect of GDF15 on BMI was observed as under the mediation of ghrelin (direct effect -0.056, p-value 0.577; indirect effect -0.199, p-value < 0.001).</p><p><strong>Conclusions: </strong>Present results provide novel insights into the role of GDF15 in eating disorders, describing its serum level in this clinical population for the first time. In addition, a positive correlation between GDF15 and ghrelin serum levels is also reported for the first time.</p>\",\"PeriodicalId\":48117,\"journal\":{\"name\":\"European Eating Disorders Review\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Eating Disorders Review\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1002/erv.70018\",\"RegionNum\":2,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Eating Disorders Review","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1002/erv.70018","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
GDF15 Is Elevated in Eating Disorders and Is Involved in the Gut-Brain Axis via Ghrelin.
Objective: GDF15 induces anorexia and visceral discomfort, regulating appetite, food intake and potentially metabolic responses. However, its role in eating disorders remains unexplored.
Method: A total of 145 participants were recruited (60 patients with anorexia nervosa, 20 with bulimia nervosa, 13 with binge eating disorder, 52 participants from the general population). Ghrelin and GDF15 serum levels were measured with immunosorbent assay kits.
Results: Ghrelin was elevated in patients with an eating disorder compared to healthy controls (age and BMI-adjusted ANCOVA, F-value 4.084, p-value 0.008). GDF15 was significantly correlated with ghrelin (Spearman rho 0.430, p-value < 0.001) and BMI (rho = -0.176, p-value = 0.025). GDF15 predicted the BMI of patients with anorexia nervosa and individuals from the general population, again being elevated at lower BMI (linear regression beta -0.254, p-value 0.005). The effect of GDF15 on BMI was observed as under the mediation of ghrelin (direct effect -0.056, p-value 0.577; indirect effect -0.199, p-value < 0.001).
Conclusions: Present results provide novel insights into the role of GDF15 in eating disorders, describing its serum level in this clinical population for the first time. In addition, a positive correlation between GDF15 and ghrelin serum levels is also reported for the first time.
期刊介绍：
European Eating Disorders Review publishes authoritative and accessible articles, from all over the world, which review or report original research that has implications for the treatment and care of people with eating disorders, and articles which report innovations and experience in the clinical management of eating disorders. The journal focuses on implications for best practice in diagnosis and treatment. The journal also provides a forum for discussion of the causes and prevention of eating disorders, and related health policy. The aims of the journal are to offer a channel of communication between researchers, practitioners, administrators and policymakers who need to report and understand developments in the field of eating disorders.
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