Noora Jantunen, Marja Raekallio, Bartlomiej Obrochta, Heidi Tapio, Luis Gracia Calvo, Rebecca Rivera Pöyhönen, Kati Hagman, Ninja Karikoski
{"title":"长时间静脉输注德托咪定对马能量代谢和尿液成分的影响。","authors":"Noora Jantunen, Marja Raekallio, Bartlomiej Obrochta, Heidi Tapio, Luis Gracia Calvo, Rebecca Rivera Pöyhönen, Kati Hagman, Ninja Karikoski","doi":"10.1016/j.vaa.2025.06.011","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To assess the effects of a 4 hour detomidine constant rate infusion (CRI) with and without a vatinoxan CRI on energy metabolism and urine composition.</p><p><strong>Study design: </strong>Randomized, blinded, crossover study.</p><p><strong>Animals: </strong>Eight Finnhorses, 587 (550-620) kg [median (range)] and 13 (4-16) years old.</p><p><strong>Methods: </strong>Horses were administered an intravenous (IV) detomidine loading dose (0.01 mg kg<sup>-1</sup>) followed by 240 minutes CRI (0.015 mg kg<sup>-1</sup> hour<sup>-1</sup>) (DET) and the same detomidine protocol combined with an IV vatinoxan loading dose (0.15 mg kg<sup>-1</sup>) and CRI (0.05 mg kg hour<sup>-1</sup>) (DET+VAT). Blood samples for glucose, insulin, non-esterified fatty acid (sNEFA), and β-hydroxybutyrate (sBHB) concentrations were collected during and for 240 minutes after CRI. Urine samples for glucose and sodium concentrations were collected at the end of CRI. Data were analysed using repeated measures ANCOVA and Wilcoxon signed-rank test.</p><p><strong>Results: </strong>Blood glucose concentrations were significantly higher during CRI with DET compared with DET+VAT (all p < 0.001). Median insulin concentration was significantly lower during CRI with DET compared with DET+VAT (p = 0.012-0.018) and peaked at the end of follow-up period. With DET+VAT CRI, sBHB and sNEFA were significantly higher compared with DET (p < 0.001-0.002, p < 0.001-0.007). Urination was more frequent during DET CRI than with DET+VAT (p = 0.020). Glucosuria was more profound with DET [6.3 (2.4-11.1) mmol L<sup>-1</sup>] than with DET+VAT [0.1 (0.0-3.1) mmol L<sup>-1</sup>] (p = 0.012). More sodium was excreted into urine with DET [49.0 (22-66) mmol L<sup>-1</sup>] than with DET+VAT [27.0 (8-43) mmol L<sup>-1</sup>] (p = 0.012).</p><p><strong>Conclusions and clinical relevance: </strong>Vatinoxan alleviated detomidine-induced hypoinsulinaemia and hyperglycaemia and diminished urination frequency, glucosuria, and natriuresis during and after a 4 hour CRI. Vatinoxan may be beneficial during standing sedation with alpha2-adrenoceptor agonists.</p>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of a long-duration intravenous infusion of detomidine, with and without vatinoxan, on equine energy metabolism and urine composition.\",\"authors\":\"Noora Jantunen, Marja Raekallio, Bartlomiej Obrochta, Heidi Tapio, Luis Gracia Calvo, Rebecca Rivera Pöyhönen, Kati Hagman, Ninja Karikoski\",\"doi\":\"10.1016/j.vaa.2025.06.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To assess the effects of a 4 hour detomidine constant rate infusion (CRI) with and without a vatinoxan CRI on energy metabolism and urine composition.</p><p><strong>Study design: </strong>Randomized, blinded, crossover study.</p><p><strong>Animals: </strong>Eight Finnhorses, 587 (550-620) kg [median (range)] and 13 (4-16) years old.</p><p><strong>Methods: </strong>Horses were administered an intravenous (IV) detomidine loading dose (0.01 mg kg<sup>-1</sup>) followed by 240 minutes CRI (0.015 mg kg<sup>-1</sup> hour<sup>-1</sup>) (DET) and the same detomidine protocol combined with an IV vatinoxan loading dose (0.15 mg kg<sup>-1</sup>) and CRI (0.05 mg kg hour<sup>-1</sup>) (DET+VAT). Blood samples for glucose, insulin, non-esterified fatty acid (sNEFA), and β-hydroxybutyrate (sBHB) concentrations were collected during and for 240 minutes after CRI. Urine samples for glucose and sodium concentrations were collected at the end of CRI. Data were analysed using repeated measures ANCOVA and Wilcoxon signed-rank test.</p><p><strong>Results: </strong>Blood glucose concentrations were significantly higher during CRI with DET compared with DET+VAT (all p < 0.001). Median insulin concentration was significantly lower during CRI with DET compared with DET+VAT (p = 0.012-0.018) and peaked at the end of follow-up period. With DET+VAT CRI, sBHB and sNEFA were significantly higher compared with DET (p < 0.001-0.002, p < 0.001-0.007). Urination was more frequent during DET CRI than with DET+VAT (p = 0.020). Glucosuria was more profound with DET [6.3 (2.4-11.1) mmol L<sup>-1</sup>] than with DET+VAT [0.1 (0.0-3.1) mmol L<sup>-1</sup>] (p = 0.012). More sodium was excreted into urine with DET [49.0 (22-66) mmol L<sup>-1</sup>] than with DET+VAT [27.0 (8-43) mmol L<sup>-1</sup>] (p = 0.012).</p><p><strong>Conclusions and clinical relevance: </strong>Vatinoxan alleviated detomidine-induced hypoinsulinaemia and hyperglycaemia and diminished urination frequency, glucosuria, and natriuresis during and after a 4 hour CRI. Vatinoxan may be beneficial during standing sedation with alpha2-adrenoceptor agonists.</p>\",\"PeriodicalId\":23626,\"journal\":{\"name\":\"Veterinary anaesthesia and analgesia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary anaesthesia and analgesia\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1016/j.vaa.2025.06.011\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1016/j.vaa.2025.06.011","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
The effects of a long-duration intravenous infusion of detomidine, with and without vatinoxan, on equine energy metabolism and urine composition.
Objective: To assess the effects of a 4 hour detomidine constant rate infusion (CRI) with and without a vatinoxan CRI on energy metabolism and urine composition.
Study design: Randomized, blinded, crossover study.
Animals: Eight Finnhorses, 587 (550-620) kg [median (range)] and 13 (4-16) years old.
Methods: Horses were administered an intravenous (IV) detomidine loading dose (0.01 mg kg-1) followed by 240 minutes CRI (0.015 mg kg-1 hour-1) (DET) and the same detomidine protocol combined with an IV vatinoxan loading dose (0.15 mg kg-1) and CRI (0.05 mg kg hour-1) (DET+VAT). Blood samples for glucose, insulin, non-esterified fatty acid (sNEFA), and β-hydroxybutyrate (sBHB) concentrations were collected during and for 240 minutes after CRI. Urine samples for glucose and sodium concentrations were collected at the end of CRI. Data were analysed using repeated measures ANCOVA and Wilcoxon signed-rank test.
Results: Blood glucose concentrations were significantly higher during CRI with DET compared with DET+VAT (all p < 0.001). Median insulin concentration was significantly lower during CRI with DET compared with DET+VAT (p = 0.012-0.018) and peaked at the end of follow-up period. With DET+VAT CRI, sBHB and sNEFA were significantly higher compared with DET (p < 0.001-0.002, p < 0.001-0.007). Urination was more frequent during DET CRI than with DET+VAT (p = 0.020). Glucosuria was more profound with DET [6.3 (2.4-11.1) mmol L-1] than with DET+VAT [0.1 (0.0-3.1) mmol L-1] (p = 0.012). More sodium was excreted into urine with DET [49.0 (22-66) mmol L-1] than with DET+VAT [27.0 (8-43) mmol L-1] (p = 0.012).
Conclusions and clinical relevance: Vatinoxan alleviated detomidine-induced hypoinsulinaemia and hyperglycaemia and diminished urination frequency, glucosuria, and natriuresis during and after a 4 hour CRI. Vatinoxan may be beneficial during standing sedation with alpha2-adrenoceptor agonists.
期刊介绍：
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
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