Caterina Vicenti, Marta Cercone, Gary Nieman, Nader M Habashi, Penny Andrews, Joshua Satalin, Pamela Velarde, Katharyn J Mitchell, Elizabeth Williams Louie, Victoria Albano, Haider Ali, Andrea King, Francesco Staffieri, Robin Gleed, Alex Bukoski, Klaus Hopster, David Hodgson, Andy Adler, Manuel Martin-Flores, Joaquin Araos
{"title":"早、晚时控适应性通气对麻醉马肺气体交换的影响。","authors":"Caterina Vicenti, Marta Cercone, Gary Nieman, Nader M Habashi, Penny Andrews, Joshua Satalin, Pamela Velarde, Katharyn J Mitchell, Elizabeth Williams Louie, Victoria Albano, Haider Ali, Andrea King, Francesco Staffieri, Robin Gleed, Alex Bukoski, Klaus Hopster, David Hodgson, Andy Adler, Manuel Martin-Flores, Joaquin Araos","doi":"10.1016/j.vaa.2025.06.007","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses.</p><p><strong>Study design: </strong>A crossover, nonrandomized, experimental study.</p><p><strong>Animals: </strong>Six healthy adult horses.</p><p><strong>Methods: </strong>Each horse underwent two anesthetics: 1) volume-controlled ventilation (VCV) began for 30 minutes before switching to APRV using the TCAV method (late TCAV, TCAV<sub>L</sub>); and 2) ventilation began immediately with TCAV (early TCAV, TCAV<sub>E</sub>). The study lasted 180 minutes, with arterial blood gases and respiratory mechanics recorded at T0 and every 30 minutes. Electrical impedance tomography (EIT) was performed at T0, T30, T90 and T180 to calculate mid-cranial regional ventilation. A two-way repeated measures analysis of variance was used for comparisons. Lung ultrasound (LUS) images were obtained from three horses at baseline (before anesthesia) and at T30, T60, T120 and T180 during each crossover to calculate a mid-caudal LUS score. No statistical analysis was performed on ultrasound data.</p><p><strong>Results: </strong>TCAV<sub>E</sub> showed significantly higher partial pressure of arterial oxygen to fraction of inspired oxygen (PaO<sub>2</sub>/FiO<sub>2</sub>) than TCAV<sub>L</sub>, whereas TCAV did not significantly affect it compared with VCV in the TCAV<sub>L</sub> group. TCAV<sub>E</sub> resulted in significantly higher tidal volumes (V<sub>T</sub>)than TCAV<sub>L</sub>, whereas in the TCAV<sub>L</sub> group, TCAV reduced V<sub>T</sub> compared with VCV. No significant differences were found in respiratory system compliance or airway driving pressure. Both TCAV<sub>E</sub> and TCAV<sub>L</sub> significantly improved dorsal lung ventilation on EIT, but TCAV<sub>L</sub> failed to reverse caudal atelectasis and consolidation seen on LUS, whereas TCAV<sub>E</sub> appeared to prevent it.</p><p><strong>Conclusions and clinical relevance: </strong>TCAV<sub>E</sub> improved oxygenation and regional ventilation, whereas TCAV<sub>L</sub> failed to improve respiratory mechanics or oxygenation compared with VCV.</p>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of early and late time-controlled adaptive ventilation on pulmonary gas exchange in anesthetized horses.\",\"authors\":\"Caterina Vicenti, Marta Cercone, Gary Nieman, Nader M Habashi, Penny Andrews, Joshua Satalin, Pamela Velarde, Katharyn J Mitchell, Elizabeth Williams Louie, Victoria Albano, Haider Ali, Andrea King, Francesco Staffieri, Robin Gleed, Alex Bukoski, Klaus Hopster, David Hodgson, Andy Adler, Manuel Martin-Flores, Joaquin Araos\",\"doi\":\"10.1016/j.vaa.2025.06.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses.</p><p><strong>Study design: </strong>A crossover, nonrandomized, experimental study.</p><p><strong>Animals: </strong>Six healthy adult horses.</p><p><strong>Methods: </strong>Each horse underwent two anesthetics: 1) volume-controlled ventilation (VCV) began for 30 minutes before switching to APRV using the TCAV method (late TCAV, TCAV<sub>L</sub>); and 2) ventilation began immediately with TCAV (early TCAV, TCAV<sub>E</sub>). The study lasted 180 minutes, with arterial blood gases and respiratory mechanics recorded at T0 and every 30 minutes. Electrical impedance tomography (EIT) was performed at T0, T30, T90 and T180 to calculate mid-cranial regional ventilation. A two-way repeated measures analysis of variance was used for comparisons. Lung ultrasound (LUS) images were obtained from three horses at baseline (before anesthesia) and at T30, T60, T120 and T180 during each crossover to calculate a mid-caudal LUS score. No statistical analysis was performed on ultrasound data.</p><p><strong>Results: </strong>TCAV<sub>E</sub> showed significantly higher partial pressure of arterial oxygen to fraction of inspired oxygen (PaO<sub>2</sub>/FiO<sub>2</sub>) than TCAV<sub>L</sub>, whereas TCAV did not significantly affect it compared with VCV in the TCAV<sub>L</sub> group. TCAV<sub>E</sub> resulted in significantly higher tidal volumes (V<sub>T</sub>)than TCAV<sub>L</sub>, whereas in the TCAV<sub>L</sub> group, TCAV reduced V<sub>T</sub> compared with VCV. No significant differences were found in respiratory system compliance or airway driving pressure. Both TCAV<sub>E</sub> and TCAV<sub>L</sub> significantly improved dorsal lung ventilation on EIT, but TCAV<sub>L</sub> failed to reverse caudal atelectasis and consolidation seen on LUS, whereas TCAV<sub>E</sub> appeared to prevent it.</p><p><strong>Conclusions and clinical relevance: </strong>TCAV<sub>E</sub> improved oxygenation and regional ventilation, whereas TCAV<sub>L</sub> failed to improve respiratory mechanics or oxygenation compared with VCV.</p>\",\"PeriodicalId\":23626,\"journal\":{\"name\":\"Veterinary anaesthesia and analgesia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary anaesthesia and analgesia\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1016/j.vaa.2025.06.007\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1016/j.vaa.2025.06.007","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Comparison of early and late time-controlled adaptive ventilation on pulmonary gas exchange in anesthetized horses.
Objective: To compare early versus late time-controlled adaptive ventilation (TCAV) for setting airway pressure release ventilation (APRV) on arterial oxygenation in dorsally recumbent anesthetized horses.
Study design: A crossover, nonrandomized, experimental study.
Animals: Six healthy adult horses.
Methods: Each horse underwent two anesthetics: 1) volume-controlled ventilation (VCV) began for 30 minutes before switching to APRV using the TCAV method (late TCAV, TCAVL); and 2) ventilation began immediately with TCAV (early TCAV, TCAVE). The study lasted 180 minutes, with arterial blood gases and respiratory mechanics recorded at T0 and every 30 minutes. Electrical impedance tomography (EIT) was performed at T0, T30, T90 and T180 to calculate mid-cranial regional ventilation. A two-way repeated measures analysis of variance was used for comparisons. Lung ultrasound (LUS) images were obtained from three horses at baseline (before anesthesia) and at T30, T60, T120 and T180 during each crossover to calculate a mid-caudal LUS score. No statistical analysis was performed on ultrasound data.
Results: TCAVE showed significantly higher partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) than TCAVL, whereas TCAV did not significantly affect it compared with VCV in the TCAVL group. TCAVE resulted in significantly higher tidal volumes (VT)than TCAVL, whereas in the TCAVL group, TCAV reduced VT compared with VCV. No significant differences were found in respiratory system compliance or airway driving pressure. Both TCAVE and TCAVL significantly improved dorsal lung ventilation on EIT, but TCAVL failed to reverse caudal atelectasis and consolidation seen on LUS, whereas TCAVE appeared to prevent it.
Conclusions and clinical relevance: TCAVE improved oxygenation and regional ventilation, whereas TCAVL failed to improve respiratory mechanics or oxygenation compared with VCV.
期刊介绍：
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
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