海洋多肽及其治疗潜力。

IF 4.9 2区 医学 Q1 CHEMISTRY, MEDICINAL
Marine Drugs Pub Date : 2025-07-15 DOI:10.3390/md23070288
Svetlana V Guryanova, Tatiana V Ovchinnikova
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引用次数: 0

摘要

海洋多肽来源于大量的水生生物,具有广泛的生物活性,具有重要的治疗潜力。本文综述了海洋多肽在抗菌、抗生物膜、抗真菌、抗病毒、抗寄生虫、细胞毒性、抗癌、免疫调节、趋化、调理、抗炎、抗衰老、皮肤保护和伤口愈合等方面的作用。本文通过阐述海洋肽的作用机制和重点研究成果,综述了海洋肽在生物医药、美容、食品、水产和农业生物技术等领域的应用前景。进一步的研究对发挥其治疗潜力至关重要,应侧重于详细的机制研究、大规模生产和临床评估,以确认其有效性和安全性,并将这些发现转化为实际应用。研究海洋多肽组合与现有药物的潜在协同效应以提高其疗效也很重要。挑战包括海洋多肽的可持续采购,因此必须考虑收获海洋生物对环境的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multifaceted Marine Peptides and Their Therapeutic Potential.

Marine peptides, derived from a great number of aquatic organisms, exhibit a broad spectrum of biological activities that hold a significant therapeutic potential. This article reviews the multifaceted roles of marine peptides, focusing on their antibacterial, antibiofilm, antifungal, antiviral, antiparasitic, cytotoxic, anticancer, immunomodulatory, chemotactic, opsonizing, anti-inflammatory, antiaging, skin-protective, and wound-healing properties. By elucidating mechanisms of their action and highlighting key research findings, this review aims to provide a comprehensive understanding of possible therapeutic applications of marine peptides, underscoring their importance in developing novel drugs as well as in cosmetology, food industry, aquatic and agriculture biotechnology. Further investigations are essential to harness their therapeutic potential and should focus on detailed mechanism studies, large-scale production, and clinical evaluations with a view to confirm their efficacy and safety and translate these findings into practical applications. It is also important to investigate the potential synergistic effects of marine peptide combinations with existing medicines to enhance their efficacy. Challenges include the sustainable sourcing of marine peptides, and therefore an environmental impact of harvesting marine organisms must be considered as well.

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来源期刊
Marine Drugs
Marine Drugs 医学-医药化学
CiteScore
9.60
自引率
14.80%
发文量
671
审稿时长
1 months
期刊介绍: Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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